Browsing by Author "Fierro, Angélica"

Now showing items 1-10 of 10

    • 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase 
      Lühr-Sierra, Susan; Vilches-Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona; Edmondson, Dale E.; Reyes Parada, Miguel; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio (ELSEVIER, 2010)
      2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided ...
    • 2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities 
      Sieveking, Ivan; Thomas, Pablo; Estévez, Juan C.; Quiñones, Natalia; Cuéllar, Mauricio A.; Villena, Juan; Espinosa Bustos, Christian; Fierro, Angélica; Tapia, Ricardo A.; Maya Arango, Juan; López Muñoz, Rodrigo; Cassels Niven, Bruce; Estévez, Ramón J.; Salas, Cristian (Elsevier, 2014)
      A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. ...
    • A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo 
      Zarate, Ana María; Espinosa Bustos, Christian; Guerrero, Simón; Fierro, Angélica; Oyarzún Ampuero, Felipe; Geoffery Quest, Andrew; Di Marcotullio, Lucía; Loricchio, Elena; Caimano, Miriam; Calcaterra, Andrea; González Quiroz, Matías; Aguirre, Adam; Meléndez, Jaime; Salas, Cristian O. (MDPI, 2021)
      The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists ...
    • Coumarin-chalcone hybrids as inhibitors of MAO-B: Biological activity and in silico studies 
      Moya Alvarado, Guillermo Adrian; Yáñez, Osvaldo; Morales, Nicole; González González, Angélica; Areche Medina, Carlos Alberto; Núñez González, Marco Tulio; Fierro, Angélica; García Beltrán, Olimpo José (MDPI, 2021)
      Fourteen coumarin-derived compounds modified at the C3 carbon of coumarin with an alpha,beta-unsaturated ketone were synthesized. These compounds may be designated as chalcocoumarins (3-cinnamoyl-2H-chromen-2-ones). Both ...
    • Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: ... 
      Fierro, Angélica; Osorio Olivares, Mauricio; Cassels Niven, Bruce; Edmondson, Dale E.; Sepúlveda Boza, Silvia; Reyes Parada, Miguel (Elsevier Ltd., 2007-05-22)
      Abstract—Four enantiomerically pure (S)-4-alkylthioamphetamine derivatives were evaluated as monoamine oxidase (MAO) inhibitors using the human and rat isoforms of the enzyme. Molecular dockings were performed in order ...
    • MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the b-position 
      Osorio Olivares, Mauricio; Caroli Rezende, Marcos; Sepúlveda Boza, Silvia; Cassels Niven, Bruce; Fierro, Angélica (Elsevier Ltd., 2004-05-26)
      Abstract—Twenty-nine arylisopropylamines, substituted at the b-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives (‘cathinones’) ...
    • Methylpiperidinium Iodides as novel antagonists for alpha 7 nicotinic acetylcholine receptors 
      López Villa, Jhon; García Colunga, Jesús; Pérez, Edwin G.; Fierro, Angélica (Frontiers Media, 2018)
      The alpha 7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target. We have designed and ...
    • Monoamine Oxidase Inhibitory Properties of Optical Isomers and N-substituted Derivatives of 4-methylthioamphetamine 
      Hurtado Guzmán, Claudio; Fierro, Angélica; Iturriaga-Vásquez, Patricio; Sepúlveda Boza, Silvia; Cassels Niven, Bruce; Reyes Parada, Miguel (Taylor & Francis Ltd, 2003-03-10)
      (6)-4-Methylthioamphetamine (MTA) was resolved into its enantiomers, and a series of N-alkyl derivatives of the parent compound, as well as its a-ethyl analogue, were prepared. The monoamine oxidase (MAO) inhibitory properties ...
    • Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors 
      Vilches-Herrera, Marcelo; Miranda-Sepúlveda, Juan; Rebolledo-Fuentes, Marco; Fierro, Angélica; Lühr, Susan; Iturriaga-Vásquez, Patricio; Cassels Niven, Bruce; Reyes Parada, Miguel (Elsevier Ltd., 2009-02-08)
      A series of naphthylisopropylamine and N-benzyl-4-methylthioamphetamine derivatives were evaluated as monoamine oxidase inhibitors. Their potencies were compared with those of a series of amphetamine derivatives, to test ...
    • Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole ... 
      Pessoa Mahana, Hernán; González Lira, Christian; Fierro, Angélica; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Ortiz Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes Parada, Miguel; Silva Matus, Paul; Saitz Barría, Claudio; Araya Maturana, Ramiro (Elsevier, 2013)
      A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter ...