Browsing by Author "García, Isaac E."

Now showing items 1-3 of 3

    • Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered ... 
      Cárdenas, César; Juretic Díaz, Nevenka Militza; Bevilacqua, Jorge; García, Isaac E.; Figueroa, Reinaldo; Hartley, Ricardo; Taratuto, Ana L.; Gejman, Roger; Riveros, Nora; Molgó, Jordi; Jaimovich Pérez, Enrique (2010)
      Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) drive calcium signals involved in skeletal muscle excitation-transcription coupling and plasticity; IP3R subtype distribution and downstream events evoked by their ...
    • Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function 
      Jara, Oscar; Acuña, Rodrigo; García, Isaac E.; Maripillán, Jaime; Figueroa, Vania; Sáez, Juan C.; Araya Secchi, Raúl; Lagos, Carlos F.; Pérez Acle, Tomás; Berthoud, Viviana M.; Beyer, Eric C.; Martínez, Agustín D. (2012)
      To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, ...
    • The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels 
      García, Isaac E.; Villanelo, Felipe; Contreras, Gustavo F.; Pupo, Amaury; Pinto, Bernardo I.; Contreras, Jorge E.; Pérez Acle, Tomás; Alvarez, Osvaldo; Latorre, Ramón; Martínez, Agustín D.; González, Carlos (Rockefeller University Press, 2018)
      Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, ...