Browsing by Author "García Beltrán, Olimpo"
Now showing items 1-20 of 24
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Areche, Carlos; Sepúlveda, Beatriz; Martin, Aurelio San; García Beltrán, Olimpo; Simirgiotis, Mario J.; Cañete, Alvaro (Royal Society of Chemistry, 2014)Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13α-hydroxyazorellane, 13β- hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy- 16,20-dioic acid ...
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García Beltrán, Olimpo; Cassels Niven, Bruce; Pérez, Claudio; Mena, Natalia P.; Núñez González, Marco; Martínez, Natalia P.; Pizarro Pavez, Paulina Ignacia; Aliaga, Margarita E. (MDPI, 2014)Two new coumarin-based “turn-off” fluorescent probes, (E)-3-((3,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS1) and (E)-3-((2,4-dihydroxybenzylidene)amino)-7-hydroxy-2H-chromen-2-one (BS2), were synthesized ...
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García Beltrán, Olimpo; Areche, Carlos; Cassels Niven, Bruce; Cuca Suárez, Luis Enrique (Elsevier, 2014)
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García Beltrán, Olimpo; Cassels Niven, Bruce; Mena, Natalia P.; Núñez González, Marco; Yáñez, Osvaldo; Caballero, Julio (Elsevier, 2014)In this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi–Hildebrand and Job plots demonstrate ...
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Iturriaga-Vásquez, Patricio; García Beltrán, Olimpo; Haddow, Main F. (2009)C18H21NO3, monoclinic, .P1211 (no. 4), a = 14.169(7) Å, b=8.533(4)Å,c=19.86(1)Å,β=104. 79(2)°, V= 2322.0 Å3,Z= 6, Rgt(F) = 0.045, wRref(F2) = 0.164, T= 100 K. © by Oldenbourg Wissenschaftsverlag.
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Iturriaga-Vásquez, Patricio; García Beltrán, Olimpo; Haddow, Mairi F. (2009)C18H21NO3, monoclinic, P121l (no. 4), a = 14.169(7) Å, b = 8.533(4) Å, c = 19.86(1) Å, β= 104.79(2)°, V = 2322.0 Å3, Z = 6, Rgt(F) = 0.045, wRref(F2) = 0.164, T = 100 K. © 2014 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer ...
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García Beltrán, Olimpo; Mena, Natalia P.; Yáñez, Osvaldo; Caballero, Julio; Vargas Cortés, Víctor; Núñez González, Marco; Cassels Niven, Bruce (2013)A new coumarin-based ‘turn-off’ fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl) propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ...
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Nuñez, Carolina; Morales, Nicole; García Beltrán, Olimpo; Mascayano, Carolina; Fierro, Angelica (Birkhauser Boston, 2017)The mechanisms of action and structural determinants of lipoxygenases inhibitors have been explored on several occasions, but many questions remain unanswered, especially about the differences of the inhibition mechanisms ...
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Mena, Natalia P.; García Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro Castillo, Vicente; Cassels Niven, Bruce; Núñez González, Marco (Elsevier B.V., 2016)
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Sepúlveda, Beatriz; Quispe, Cristina; Simirgiotis, Mario; García Beltrán, Olimpo; Areche Medina, Carlos (Elsevier, 2016)Mulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the ...
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Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library Science, 2015)Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover ...
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Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library of Science, 2015)© 2015 Aguirre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the original ...
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García Beltrán, Olimpo; Santos, José; Fuentealba, Sandra; Torre, Pedro de la; Pavez, Paulina; Mena Jiménez, Natalia; Núñez González, Marco; Aliaga, Margarita (Elsevier, 2015)We kinetically studied the reaction between endogenous thiols such as -c-glutamylcysteine (c-Glu-Cys), cysteine (Cys), glutathione (GSH), homocysteine (Hcy), cysteinylglycine (Cys-Gly), and dihydrolipoic acid (DHLA)- ...
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Iturriaga-Vásquez, Patricio; Carbone, Annalisa; García Beltrán, Olimpo; Livingstone, Phil D.; Biggin, Philip C.; Cassels Niven, Bruce; Wonnacott, Susan; Zapata-Torres, Gerald; Bermúdez, Isabel (The American Society for Pharmacology and Experimental Therapeutics, 2010-06-14)The Erythrina alkaloids erysodine and dihydro- -erythroidine (DH E) are potent and selective competitive inhibitors of 4 2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
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Iturriaga-Vásquez, Patricio; Carbone, Annalisa; García Beltrán, Olimpo; Livingstone, Phil D.; Biggin, Philip C.; Cassels Niven, Bruce; Wonnacott, Susan; Zapata Torres, Gerald Amilcar; Bermúdez, Isabel (AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2010-06-14)(DH E) are potent and selective competitive inhibitors of 4 2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants of the sensitivity of this receptor subtype to inhibition ...
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Iturriaga-Vásquez, Patricio; Carbone, Annalisa; García Beltrán, Olimpo; Livingstone, Phil D.; Biggin, Philip C.; Cassels Niven, Bruce; Wonnacott, Susan; Zapata Torres, Gerald; Bermudez, Isabel (American Society for Pharmacology and Experimental Therapy, 2010)The Erythrina alkaloids erysodine and dihydro-β-erythroidine (DHβE) are potent and selective competitive inhibitors of α4β2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
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Areche, Carlos; Fernández Burgos, Ronald; De Terrones, Teresa Cano; Simirgiotis, Mario; García Beltrán, Olimpo; Bórquez, Jorge; Sepúlveda, Beatriz (MDPI AG, 2019)Mulinum crassifolium Phil. (Apiaceae) is an endemic shrub from Chile commonly used as infusion in traditional medicine to treat diabetes, bronchial and intestinal disorders and stomach ailments, including ulcers. From the ...
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Núñez, M.; Aguirre, P.; Muñoz, Y.; García Beltrán, Olimpo (Wiley & Sons, 2015)
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Mena, Natalia P.; García Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro Castillo, Vicente; Cassels Niven, Bruce; Núñez González, Marco (Elsevier, 2015)Abundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as ...
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Areche Medina, Carlos; Benites, Julio; Cornejo, Alberto; Ruiz, Lina M.; García Beltrán, Olimpo; Simirgiotis, Mario J.; Sepúlveda, Beatriz (2015)Ten known meroterpenoids and the new meroterpenoid 7 were isolated from the Chilean seaweed Stypopodium flabelliforme as their acetylated derivatives. Furthermore, the known metabolite taondiol has been isolated for the ...