Browsing by Author "García González, Paulina"

Now showing items 1-9 of 9

    • Blocking of p38 and Transforming Growth Factor 
      Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello Cáceres, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Ribeiro, Carolina Hager; Molina Sampayo, María Carmen; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (American College of Rheumatology, 2013)
      Objective. Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to ...
    • Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic ... 
      Gárate, David; Rojas Colonelli, Nicole; Peña, Corina; Salazar, Lorena; Abello, Paula; Pesce Reyes, Bárbara; Aravena, Octavio; García González, Paulina; Hager Ribeiro, Carolina; Molina, María C.; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2013)
      Objective Dendritic cells (DCs) modulated with lipopolysaccharide (LPS) are able to reduce inflammation when therapeutically administered into mice with collagen-induced arthritis (CIA). The aim of this study was to uncover ...
    • Dysregulated immune responses in COVID-19 patients correlating with disease severity and invasive oxygen ... 
      García González, Paulina; Tempio Sepúlveda, Fabián Ignacio; Fuentes, Camila; Merino, Consuelo; Vargas, Leonardo; Simon, Valeska; Ramírez Pereira, Mirliana; Rojas, Verónica; Tobar Almonacid, Eduardo Andres; Landskron Ramos, Glauben Tamara; Araya, Juan Pablo; Navarrete, Mariela; Bastías Oñate, Carla Belén; Tordecilla Fernández, Rocío Pilar; Varas, Macarena A.; Maturana, Pablo; Marcoleta Caldera, Andrés Esteban; Allende Connelly, Miguel Luis; Naves Pichuante, Rodrigo Antonio; Hermoso, Marcela Alejandra; Salazar Onfray, Flavio Andrés; López Nitsche, Mercedes Natalia; Bono Merino, María Rosa; Osorio Olivares, Fabiola Beatriz (Frontiers Media, 2021)
      The prognosis of severe COVID-19 patients has motivated research communities to uncover mechanisms of SARS-CoV-2 pathogenesis also on a regional level. In this work, we aimed to understand the immunological dynamics of ...
    • Function in the development of neurodegenerative diseases 
      García González, Paulina; Cabral Miranda, Felipe; Hetz Flores, Claudio; Osorio Olivares, Fabiola (Frontiers Media S.A., 2018)
      Copyright © 2018 García-González, Cabral-Miranda, Hetz and Osorio. Emerging evidence suggests that the immune and nervous systems are in close interaction in health and disease conditions. Protein aggregation and proteostasis ...
    • Gene expression profiling of human monocyte-derived dendritic cells - searching for molecular regulators ... 
      Schinnerling, Katina; García González, Paulina; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2015)
      The ability of dendritic cells (DCs) to initiate and modulate antigen-specific immune responses has made them attractive targets for immunotherapy. Since DC research in humans is limited by the scarcity of DC populations ...
    • Human cDC1s display constitutive activation of the UPRsensor IRE1 
      García González, Paulina; Fernández, Dominique; Gutiérrez Cabrera, Diane; Parra Cordero, Mauro; Osorio Olivares, Fabiola (Wiley, 2022)
      The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation ...
    • Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by Myc 
      García González, Paulina; Maggi, Jaxaira; Schinnerling, Katina; Sepúlveda Gutiérrez, Alejandro; Soto, Lilian; Neira, Oscar; Mehdi, Ahmed M.; Nel, Hendrik J.; Pesce, Bárbara; Aravena, Octavio; Molina, María Carmen; Catalán, Diego; Thomas, Ranjeny; Verdugo Salgado, Ricardo (Frontiers Media S.A., 2019)
      Copyright © 2019 García-González, Maggi, Schinnerling, Sepúlveda-Gutiérrez, Soto, Neira, Mehdi, Nel, Pesce, Aravena, Molina, Catalán, Thomas, Verdugo and Aguillón.The potential of tolerogenic dendritic cells (tolDCs) to ...
    • A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that ... 
      García González, Paulina; Morales, Rodrigo; Hoyos, Lorena; Maggi, Jaxaira; Campos, Javier; Pesce Reyes, Bárbara; Gárate, David; Larrondo Lillo, Milton; González González, Rodrigo; Soto Sáez, Lilian; Ramos, Verónica; Tobar, Pía; Molina, María Carmen; Pino Lagos, Karina; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (BioMed Central, 2013)
      Background: Generation of tolerogenic dendritic cells (TolDCs) for therapy is challenging due to its implications for the design of protocols suitable for clinical applications, which means not only using safe products, ...
    • Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid ... 
      Schinnerling, Katina; Soto, Lilian; García González, Paulina; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (Elsevier, 2015)
      To date, the available options to treat autoimmune diseases such as rheumatoid arthritis (RA) include traditional corticoids and biological drugs, which are not exempt of adverse effects. The development of cellular ...