Browsing by Author "Gillette, Thomas G."

Now showing items 1-11 of 11

    • Cardiac Plasticity in Health and Disease 
      Gondalia, Raj B.; Rothermel, Beverly A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Springer Science+Business Media, 2012)
    • Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy 
      Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Cooperative binding of ETS2 and NFAT links erk1/2 and calcineurin signaling in the pathogenesis of cardiac ... 
      Luo, Yuxuan; Jiang, Nan; May, Herman I.; Luo, Xiang; Ferdous, Anwerul; Schiattarella, Gabriele G.; Chen, Guihao; Li, Qinfeng; Li, Chao; Rothermel, Beverly A.; Jiang, Dingsheng; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2021)
      Background: Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK ...
    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy 
      Troncoso, Rodrigo; Vicencio, José Miguel; Parra, Valentina; Nemchenko, Andriy; Kawashima, Yuki; Campo, Andrea del; Toro, Barbra; Battiprolu, Pavan K.; Aranguiz, Pablo; Chiong Lay, Mario; Yakar, Shoshana; Gillette, Thomas G.; Hill, Joseph A.; Abel, Evan Dale; LeRoith, Derek; Lavandero González, Sergio (European Society of Cardiology, 2012)
      Aims Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotec ...
    • Histone deacetylase inhibition blunts ischemia/reperfusion Injury by inducing cardiomyocyte autophagy 
      Xie, Min; Kong, Yongli; Tan, Wei; May, Herman; Battiprolu, Pavan K.; Pedrozo Cibils, Zully; Wang, Zhao V.; Morales, Cyndi; Luo, Xiang; Cho, Geoffrey; Jiang, Nan; Jessen, Michael E.; Warner, John J.; Lavandero González, Sergio; Gillette, Thomas G.; Turer, Aslan T.; Hill, Joseph A. (American Hearth Association, 2014)
      Background—Reperfusion accounts for a substantial fraction of the myocardial injury occurring with ischemic heart disease. Yet, no standard therapies are available targeting reperfusion injury. Here, we tested the hypothesis ...
    • Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression 
      Morales, Cyndi R.; Li, Dan L.; Pedrozo Cibils, Zully; May, Herman I.; Jiang, Nan; Kyrychenko, Viktoriia; Cho, Geoffrey; Kim, Soo Young; Wang, Zhao V.; Rotter, David; Rothermel, Beverly A.; Schneider, Jay W.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Amer Assoc Advancement Science, 2016)
      Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...
    • Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice 
      Battiprolu, Pavan K.; Hojayev, Berdymammet; Jiang, Nan; Wang, Zhao V.; Luo, Xiang; Iglewski, Myriam; Shelton, John M.; Gerard, Robert D.; Rothermel, Beverly A.; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (AMER SOC CLINICAL INVESTIGATION INC, 2012-03)
      The leading cause of death in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and function, independent of hypertension or coronary disease. However, ...
    • Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability 
      Pedrozo Cibils, Zully; Criollo Céspedes, Alfredo; Battiprolu, Pavan K.; Morales, Cyndi R.; Contreras Ferrat, Ariel Eduardo; Fernández, Carolina; Jiang, Nan; Luo, Xiang; Caplan, Michael J.; Somlo, Stefan; Rothermel, Beverly A.; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Lippicott Williams & Wilkins, 2015)
      Background-L-type calcium channel activity is critical to afterload-induced hypertrophic growth of the heart. However, the mechanisms governing mechanical stress-induced activation of L-type calcium channel activity are ...
    • Regulation of autophagy by Insulin/IGF-1 signaling pathways 
      Troncoso, Rodrigo; Vásquez Trincado, César; Campo, Andrea del; Gatica, Damián; Morales, Pablo; Paredes, Felipe; Gutiérrez, Tomás; López Crisosto, Camila; Lavandero González, Sergio; Torrealba, Natalia; García Nannig, Lorena; Díaz Araya, Guillermo; Battiprolu, Pavan K.; Nemchenko, Andriy; Ferdous, Anwarul; Gillette, Thomas G.; Hill, Joseph A. (Nova Science Publishers, 2012)
    • Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway 
      Wang, Zhao V.; Deng, Yingfeng; Gao, Ningguo; Pedrozo Cibils, Zully; Li, Dan L.; Morales, Cyndi R.; Criollo Céspedes, Alfredo; Luo, Xiang; Tan, Wei; Jiang, Nan; Lehrman, Mark A.; Rothermel, Beverly A.; Lee, Ann Hwee; Lavandero González, Sergio; Mammen, Pradeep P .A.; Ferdous, Anwarul; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A. (Elsevier, 2014-03-13)
      The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the ...
    • Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ... 
      Schiattarella, Gabriele G.; Altamirano, Francisco; Young Kim, Soo; Tong, Dan; Ferdous, Anwarul; Piristine, Hande; Dasgupta, Subhajit; Wang, Xuliang; French, Kristin M.; Villalobos, Elisa; Spurgin, Stephen B.; Waldman, Maayan; Jiang, Nan; May, Herman I.; Hill, Theodore M.; Luo, Yuxuan; Yoo, Heesoo; Zaha, Vlad G.; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2021)
      Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular ...