Browsing by Author "Giralt, Ernest"
Now showing items 1-15 of 15
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(AMER CHEMICAL SOC, 2004-07-23)The efficient synthesis of tetrapeptide 5 containing, in alternation, cyclobutane and beta-alanine residues is described. NMR experiments both at low temperature in CDCl3 and at 298 K in DMSOd(6) solutions show the ...
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(PORTLAND PRESS, 2002-09-15)The aim of the present study was to evaluate the capacity of synthetic L- and D-peptides encompassing the HIV-1(BRU) gp160 REKR cleavage site to interfere with HIV and simian immunodeficiency virus (SIV) replication and ...
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(FEDERATION AMER SOC EXP BIOL., 2005-05)One of the hallmarks of Alzheimer's disease is the self-aggregation of the amyloid beta peptide (A beta) in extracellular amyloid fibrils. Among the different forms of A beta, the 42-residue fragment (A beta(1-42)) readily ...
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(SPRINGER, 2008-11)Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
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(American Chemical Society, 2008-05-30)In a previous work, we studied the interaction of -amyloid fibrils (A ) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the ...
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(AMER CHEMICAL SOC, 2008-06)In a previous work, we studied the interaction of P-amyloid fibrils (A beta) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the peptide ...
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(EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2001-11)We investigated the effects of alpha1-antitrypsine Portland variant (alpha1-PDX) and decanoylRVKRchloromethylketone (decRVKRcmk) on HIV-2(ROD) replication in the Jurkat lymphoblastoid cell line. To this end, cells were ...
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(BioMed Central Ltd., 2004-06-04)Arabidopsis thaliana copper metallochaperone CCH is a functional homologue of yeast antioxidant ATXI, involved in cytosolic copper transport. In higher plants, CCH has to be transported to specialised cells through ...
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(ELSEVIER, 2006-03)In recent years, cell-penetrating peptides have proven to be an efficient intracellular delivery system. The mechanism for CPP internalisation, which first involves interaction with the extracellular matrix, is followed ...
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(AMER CHEMICAL SOC, 2006-01)The local heat delivered by metallic nanoparticles selectively attached to their target can be used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this principle to protein aggregates, in ...
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(MDPI, 2021)Gold nanoparticles (AuNPs) have been shown to be outstanding tools for drug delivery and biomedical applications, mainly owing to their colloidal stability, surface chemistry, and photothermal properties. The biocompatibility ...
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(Dove Medical Press, 2015)An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration ...
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(AMER CHEMICAL SOC, 2006-07-05)The results presented here show that elementary design enhancements have led to a 20-fold increase in the cellular uptake properties of a Pro-rich cell-penetrating peptide. These results are relevant not only due to the ...
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(American Chemical Society, 2013)Gold nanorods used in therapy and diagnosis must be nontoxic and stable in biological media and should be specific for the target. The complete combination of these three factors has hindered the use of gold nanorods ...
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(AMER CHEMICAL SOC, 2003-12-12)3-Amino-delta-valerolactams trans-11a-c were synthesized through conjugate addition and Curtius rearrangement and converted into Fmoc-{Trp-Gly}, Fmoc-{Ile-Gly}, and Fmoc-{Phe-Gly} pseudo-dipeptides. Conformational analyses ...
