Browsing by Author "Giussani, Dino A."

Now showing items 1-13 of 13

    • Adrenergic and vasopressinergic contributions to the cardiovascular response to acute hypoxaemia in the llama fetus 
      Giussani, Dino A.; Riquelme González, Raquel; Sanhueza, E. M.; Hanson, M. A.; Blanco, C. E.; Llanos Mansilla, Jorge (CAMBRIDGE UNIV PRESS, 1999-02-15)
      1. The effects of ft tal intravenous treatment with phentolamine or a vasopressinergic V-1-receptor antagonist on the fetal cardiovascular responses to acute hypoxaemia in the llama were investigated. 2. Six llama fetuses ...
    • Carbon monoxide: a novel pulmonary artery vasodilator in neonatal llamas of the Andean altiplano 
      Herrera Videla, Emilio; Reyes, Roberto V.; Giussani, Dino A.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Ebensperger Darrouy, Germán; Casanello, Paola; Méndez, Natalia; Ebensperger, Renato; Sepúlveda Kattan, Esteban; Pulgar, Víctor M.; Cabello, Gertrudis; Blanco, Carlos E.; Hanson, Mark A.; Parer, Julian T.; Llanos Mansilla, Jorge (European Society of Cardiology, 2008)
      Aims To study the nitric oxide (NO) and carbon monoxide roles in the regulation of the pulmonary circulation in lowland and highland newborn sheep and llamas. Methods and results We used neonatal sheep (Ovis aries) and ...
    • Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the ... 
      Herrera Videla, Emilio; Rojas, Rodrigo T.; Krause, Bernardo J.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Giussani, Dino A.; Parer, Julian T.; Llanos Mansilla, Jorge (WILEY-BLACKWELL, 2016)
      High-altitude hypoxia causes intrauterine growth restriction and cardiovascular programming. However, adult humans and animals that have evolved at altitude show certain protection against the effects of chronic hypoxia. ...
    • Evolving in thin air—Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme González, Raquel; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza Reinoso, Emilia; Pulgar, Víctor M.; Behn Thiele, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (ELSEVIER, 2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the lowfetal arterial PO2 of all species, but also the likely ...
    • Fetal and postnatal pulmonary circulation in the Alto Andino 
      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, R. V.; Pulgar, V. M.; Serón Ferré, María; Díaz Beneventi, Mauricio; Parer, J. T.; Giussani, Dino A.; Moraga, F. A.; Riquelme González, Raquel (Elsevier, 2011)
      Lowland mammals at high altitude constrict the pulmonary vessels, augmenting vascular resistance and developing pulmonary arterial hypertension. In contrast, highland mammals, like the llama, do not present pulmonary ...
    • High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep 
      Herrera Videla, Emilio; Pulgar, Víctor M.; Riquelme González, Raquel; Sanhueza Reinoso, Emilia; Reyes, Roberto V.; Ebensperger Darrouy, Germán; Parer, Julian T.; Valdéz, Enrique A.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A.; Llanos Mansilla, Jorge (AMER PHYSIOLOGICAL SOC, 2007-06)
      Perinatal exposure to chronic hypoxia induces sustained pulmonary hypertension and structural and functional changes in both pulmonary and systemic vascular beds. The aim of this study was to analyze consequences of ...
    • Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of ... 
      Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction ... 
      Hansell, Jeremy A.; Richter, Hans G.; Camm, Emily J.; Herrera Videla, Emilio Augusto; Blanco, Carlos E.; Villamor, Eduardo; Patey, Olga V.; Lock, Mitchell C.; Trafford, Andrew W.; Galli, Gina L. J.; Giussani, Dino A. (Wiley, 2021)
      Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed ...
    • Melatonin modulates the fetal cardiovascular defense response to acute hypoxia 
      Thakor, Avnesh S.; Allison, Beth J.; Niu, Youguo; Botting, Kimberley J.; Serón Ferré, María; Herrera Videla, Emilio; Giussani, Dino A. (Wiley & Sons, 2015)
      Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction. However, the ...
    • Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in ... 
      McGillick, Erin; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie; Kane, Andrew; Herrera Videla, Emilio Augusto; Morrison, Janna L.; Giussani, Dino A. (Springernature, 2021)
      BACKGROUND: In the fetus, the appropriate balance of prooxidants and antioxidants is essential to negate the detrimental effects of oxidative stress on lung maturation. Antioxidants improve respiratory function in postnatal ...
    • Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in ... 
      Sánchez, G.; Liberona, Leonel; Llanos Mansilla, Jorge; Sanhueza, E. M.; Giussani, Dino A.; Blanco, C. E.; Hanson, M. A.; Riquelme González, Raquel (CAMBRIDGE UNIV PRESS, 2002-10-01)
      The hypothesis that nitric oxide plays a key role in the regulation of adrenal blood flow and plasma concentrations of cortisol and catecholamines under basal and hypoxaemic conditions in the llama fetus was tested. At ...
    • Reduced Cystathionine g-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular ... 
      Cindrova Davies, Tereza; Herrera Videla, Emilio; Niu, Youguo; Kingdom, John; Giussani, Dino A.; Burton, Graham J. (Elsevier, 2013)
      Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in ...
    • Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia 
      Sanhueza Reinoso, Emilia; Riquelme González, Raquel; Herrera Videla, Emilio; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A.; Llanos Mansilla, Jorge (AMER PHYSIOLOGICAL SOC, 2005-09)
      The fetal llama responds to hypoxemia, with a marked peripheral vasoconstriction but, unlike the sheep, with little or no increase in cerebral blood flow. We tested the hypothesis that the role of nitric oxide (NO) may be ...