Browsing by Author "González Hormazábal, Patricio"

Now showing items 1-9 of 9

    • Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR- 196a2, Pre-miR-423, miR-608 and ... 
      Morales, Sebastián; Gulppi, Felipe; González Hormazábal, Patricio; Fernández Ramires, Ricardo; Bravo, Teresa; Reyes, José; Poblete Gómez, Fernando Andrés; Waugh, Enrique; Jara Sosa, Lilian (BioMed Central, 2016)
      Background: MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-stranded RNAs capable of regulating gene expression by suppressing translation or degrading mRNAs. Single nucleotide polymorphisms (SNP) ...
    • Effect of a single dose of malathion on spermatogenesis in mice 
      Bustos Obregón, Eduardo; González Hormazábal, Patricio (2003)
      Aim: To observe the acute effect of the organophosphorous insecticide malathion on testicular function in mice. Methods: The effects of a single dose of malathion [240 mg/kg (1/12 LD 50)] on plasma acetylcholinesterase ...
    • Estudio genómico de riesgo para cáncer gástrico y su asociación con ancestría en la población chilena 
      Retamales Ortega, Rocío Mariana (Universidad de Chile, 2020)
      El cáncer gástrico (CG) es la principal causa de muerte oncológica en Chile, no tiene síntomas específicos y tiene una tasa de sobrevida a 5 años de hasta un 20% debido a su diagnóstico en estadíos tardíos. La tasa de ...
    • Major Histocompatibility Complex Class I-Related Chain A (MICA) allelic variants associate with susceptibility ... 
      Toledo Stuardo, Karen; Ribeiro, Carolina H.; Canals Cifuentes, María Andrea; Morales, Marcela; Gárate, Valentina; Rodríguez Siza, José; Tello, Samantha; Bustamante, Marco; Armisen, Ricardo; Matthies Eyzaguirre, Douglas Johans; Zapata Torres, Gerald Amilcar; González Hormazábal, Patricio; Molina Sampayo, María Carmen (Frontiers Media, 2021)
      Gastric cancer (GC) is the fifth most prevalent type of cancer worldwide. Gastric tumor cells express MICA protein, a ligand to NKG2D receptor that triggers natural killer (NK) cells effector functions for early tumor ...
    • NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with ... 
      González Hormazábal, Patricio; Peláez, Diana; Musleh Katan, Maher Elías; Bustamante, Marco; Stambuk Mayorga, Juan Antonio; Pisano, Raúl; Valladares Hernández, Héctor; Lanzarini Sobrevía, Enrique Giovani; Chiong, Héctor; Suazo Sanhueza, José Lorenzo; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel Edgardo; Castro, Gonzalo; Jara Sosa, Lilian Elena; Berger, Zoltan (Sociedad de Biología de Chile, 2021)
      BackgroundHelicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against ...
    • Polymorphisms in RAS/RAF/MEK/ERK pathway are associated with gastric cancer 
      González Hormazábal, Patricio; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Suazo, Jose; Gonzalo Castro, V.; Jara, Lilian; Berger, Zoltan (MDPI AG, 2019)
      The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers ...
    • RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population 
      Jara, Lilian; Acevedo, Monica L.; Blanco, Rafael; Castro, Victor G.; Bravo, Teresa; Gómez, Fernando; Waugh, Enrique; Peralta, Octavio; Cabrera, Elsa; Reyes, José M.; Ampuero Llanos, Sandra; González Hormazábal, Patricio (2007)
      Several studies have reported that mutations in genes involved in maintenance of genome integrity may be responsible for increased cancer risk. Human RAD51, known to function in DNA repair, interacts with a number of ...
    • Role of cytokine gene polymorphisms in gastric cancer risk in Chile 
      González Hormazábal, Patricio; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Escandar, Susana; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, V. Gonzalo; Rubio-Reyes, Cristian; Jara, Lilian; Berger, Zoltan (International Institute of Anticancer Research, 2014)
      Aim: To assess the role of pro- and anti-inflammatory polymorphisms in gastric cancer susceptibility. Patients and Methods: We genotyped 12 polymorphisms in eight cytokine genes (Interleukin-1β-IL1B-, IL8, IL17A, IL17F, ...
    • Variants in DNA double-strand break repair genes and risk of familial breast cancer in a South American population 
      Jara, Lilian; Dubois, Karen; Gaete, Daniel; De Mayo, Tomas; Ratkevicius, Nikalai; Bravo, Teresa; Margarit, Sonia; Blanco, Rafael; Gómez, Fernando; Waugh, Enrique; Peralta, Octavio; Reyes, Jose M.; Ibáñez, Gladys; González Hormazábal, Patricio (Springer New York, 2010)
      The double-strand break (DSB) DNA repair pathway has been implicated in breast cancer (BC). RAD51 and its paralogs XRCC3 and RAD51D play an important role in the repair of DSB through homologous recombination (HR). Some ...