Browsing by Author "Guerrero, Simón"

Now showing items 1-6 of 6

    • A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo 
      Zarate, Ana María; Espinosa Bustos, Christian; Guerrero, Simón; Fierro, Angélica; Oyarzún Ampuero, Felipe; Geoffery Quest, Andrew; Di Marcotullio, Lucía; Loricchio, Elena; Caimano, Miriam; Calcaterra, Andrea; González Quiroz, Matías; Aguirre, Adam; Meléndez, Jaime; Salas, Cristian O. (MDPI, 2021)
      The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists ...
    • Enhanced cellular uptake of H-chain human ferritin containing gold nanoparticles 
      Moglia Fernández, Ítalo Arnoldo; Margarita, Santiago; Guerrero, Simón; Soler Jauma, Mónica; Olivera Nappa, Alvaro María; Kogan, Marcelo Javier (MDPI, 2021)
      Gold nanoparticles (AuNP) capped with biocompatible layers have functional optical, chemical, and biological properties as theranostic agents in biomedicine. The ferritin protein containing in situ synthesized AuNPs has ...
    • Functionalization of stable fluorescent nanodiamonds towards reliable detection of biomarkers for Alzheimer's ... 
      Morales Zavala, Francisco; Casanova Morales, Nathalie; Gonzalez, Raúl B.; Chandia Cristi, América; Estrada, Lisbell D.; Alvizu, Ignacio; Waselowski, Víctor; Guzmán, Fanny; Guerrero, Simón; Oyarzún Olave, Marisol; Rebolledo, Cristian; Rodríguez, Enrique; Armijo, Julien; Bhuyan, Heman; Favre, Mario; Alvarez, Alejandra R.; Kogan Bocian, Marcelo; Maze, Jerónimo R. (BMC, 2018)
      Background: Stable and non-toxic fluorescent markers are gaining attention in molecular diagnostics as powerful tools for enabling long and reliable biological studies. Such markers should not only have a long half-life ...
    • Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis 
      Araya, Eyleen; Olmedo, Ivonne; Bastus, Neus G.; Guerrero, Simón; Puntes, Víctor F.; Giralt, Ernest; Kogan Bocian, Marcelo (SPRINGER, 2008-11)
      Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
    • Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches 
      Velasco Aguirre, Carolina; Morales, Francisco; Gallardo Toledo, Eduardo; Guerrero, Simón; Giralt, Ernest; Araya, Eyleen; Kogan Bocian, Marcelo (Dove Medical Press, 2015)
      An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration ...
    • Stable Conjugates of Peptides with Gold Nanorods for Biomedical Applications with Reduced Effects on Cell Viability 
      Adura, Carolina; Guerrero, Simón; Salas, Edison; Medel, Luis; Riveros, Ana; Mena, Juan; Arbiol, Jordi; Albericio, Fernando; Giralt, Ernest; Kogan Bocian, Marcelo (American Chemical Society, 2013)
      Gold nanorods used in therapy and diagnosis must be nontoxic and stable in biological media and should be specific for the target. The complete combination of these three factors has hindered the use of gold nanorods ...