Browsing by Author "Herrera Marschitz, Mario"

Now showing items 1-6 of 6

    • A dual treatment blocks alcohol binge-drinking relapse: microbiota as a new player 
      Ezquer, Fernando; Quintanilla González, María Elena; Morales Retamales, Eugenia; Santapaul, Daniela; Munita, José Manuel; Moya Flores, Francisco; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy (Elsevier, 2022)
      Rationale: Gut microbiota communicates information to the brain. Some animals are born with a gut microbiota that predisposes to high alcohol consumption, and transplantation of fecal material from alcoholics to mice ...
    • Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like ... 
      Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Lespay Rebolledo, Carolyne; Herrera Marschitz, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2019)
      © 2017 Society for the Study of Addiction Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells ...
    • Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and ... 
      Rivera Meza, Mario; Vásquez, David; Quintanilla González, María Elena; Lagos, Diego; Rojas, Braulio; Herrera Marschitz, Mario; Israel Jacard, Yedy (Elsevier Ltd, 2019)
      © 2018 Elsevier Ltd A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic ...
    • Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational ... 
      Israel Jacard, Yedy; Quintanilla González, María Elena; Ezquer, Fernando; Morales, Paola; Rivera Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera Marschitz, Mario (Nature Publishing Group, 2019)
      Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
    • Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor ... 
      Berríos Cárcamo, Pablo; Rivera Meza, Mario; Herrera Marschitz, Mario; Zapata Torres, Gerald (Blackwell Publishing Ltd, 2019)
      (R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
    • Silencing brain catalase expression reduces ethanol intake in developmentally-lead-exposed rats 
      Mattalloni, Mara Soledad; Albrecht, Paula Alejandra; Salinas Luypaert, Catalina; Deza-Ponzio, Romina; Quintanilla González, María Elena; Herrera Marschitz, Mario; Cancela, Liliana Marina; Rivera Meza, Mario; Virgolini, Miriam Beatriz (Elsevier B.V., 2019)
      © 2018 Elsevier B.V. Lead (Pb) is a developmental neurotoxicant. We have demonstrated that perinatally Pb-exposed rats consume more ethanol than their control counterparts, a response that seems to be mediated by catalase ...