Browsing by Author "Huenchuguala, Sandro"

Now showing items 1-3 of 3

Artículo

Aminochrome induces irreversible mitochondrial dysfunction by inducing autophagy dysfunction in Parkinson's Disease

Segura Aguilar, Juan; Huenchuguala, Sandro (Frontiers Media, 2018)
Artículo

DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

Muñoz, Patricia; Cárdenas, Sergio; Huenchuguala, Sandro; Briceño, Andrea; Couve, Eduardo; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Oxford University Press, 2015)

It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
Artículo

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

Urriola Cuevas, Carlos; Huenchuguala, Sandro; Muñoz, Patricia; Villa, Mónica; Paris Pizarro, Irmgard; Mannervik, Bengt; Segura Aguilar, Juan (Springer, 2015)

U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) ...