Browsing by Author "Kästner, Johannes"

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Artículo

Exploration of the activation mechanism of the epigenetic regulator MLL3: A QM/MM study

Miranda Rojas, Sebastián; Blanco Esperguez, Kevin; Tuñón, Iñaki; Kästner, Johannes; Mendizábal Emaldia, Fernando Javier (MDPI, 2021)

The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several ...
Artículo

Unraveling the role of the tyrosine tetrad from the binding site of the epigenetic writer MLL3 in the ...

Blanco Esperguez, Kevin; Tuñón, Iñaki; Kästner, Johannes; Mendizábal Emaldía, Fernando Javier; Miranda Rojas, Sebastián (MDPI, 2022)

MLL3, also known as KMT2C, is a lysine mono-methyltransferase in charge of the writing of an epigenetic mark on lysine 4 from histone 3. The catalytic site of MLL3 is composed of four tyrosines, namely, Y44, Y69, Y128, and ...