Browsing by Author "León, Oscar"
Now showing items 1-4 of 4
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Robles Planells, Claudia (Universidad de Chile, 2018-09)El melanoma maligno es un tipo de cáncer a la piel de baja incidencia, pero elevada tasa de mortalidad, por ello continúa la búsqueda de terapias complementarias para su tratamiento. La viroterapia antitumoral aprovecha ...
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Benleulmi, Salah S.; Matysiak, Julien; Henríquez, Rodrigo R.; Vaillant, Cédric; Lesbats, Paul; Calmels, Christina; Naughtin, Monica; León, Oscar; Skalka, Anna Marie; Ruff, Marc; Lavigne, Marc; Andreola, Marie Line; Parissi, Vincent (BioMed Central, 2015)Background: Retroviral integration depends on the interaction between intasomes, host chromatin and cellular targeting cofactors as LEDGF/p75 or BET proteins. Previous studies indicated that the retroviral integrase, by ...
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Acevedo, Mónica L.; Arbildúa, José Jaime; Monasterio Opazo, Octavio; Toledo, Héctor; León, Oscar (2010)X-ray diffraction data on a few retroviral integrases show a flexible loop near the active site. By sequence alignment, the peptide region 207-218 of Mo-MLV IN appears to correspond to this flexible loop. In this study, ...
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Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, Maria L.; Corvalán, Alejandro H.; Soto Rifo, Ricardo; Aguayo, Francisco (Public Library of Science, 2015)We have previously shown a functional interaction between human papillomavirus type 16 (HPV-16) E6 and E7 oncoproteins and cigarette smoke condensate (CSC) in lung cells suggesting cooperation during carcinogenesis. The ...