Browsing by Author "Maccioni Baraona, Ricardo"
Now showing items 1-20 of 53
-
(Kluwer Academic Publishers, 1995)Microtubule-associated proteins (MAPs) interact with tubulin in vitro and in vivo. Despite that there is a large amount of information on the roles of these proteins in neurons, the data on non-neuronal MAPs or MAPs-related ...
-
(1993)Abstract: Much indirect evidence suggests that the interconnections of actin microfilaments with the microtubule system are mediated by microtubule‐associated proteins (MAPs). In this study we provide new data to support ...
-
(2002)Intracellular reactive iron is a source of free radicals and a possible cause of cell damage. In this study, we analyzed the changes in iron homeostasis generated by iron accumulation in neuroblastoma (N2A) cells and ...
-
(ELSEVIER, 2006-02)Alzheimer's disease(AD) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of A beta peptide and the presence of intraneuronal aggregates of neurofibillary ...
-
(2006)Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of Aβ peptide and the presence of intraneuronal aggregates of neurofibillary ...
-
(Universisdad de Chile, 1993)El citoesqueleto es una compleja y dinámica red intracelular de filamentos intermedios que incluye filamentos de actina, microtúbulos, filamentos intermedios y sus proteínas asociadas. Las proteínas asociadas a microtúbulos ...
-
(2004)Production of nitric oxide (NO) by glial cells has been proposed to mediate cytotoxic effects on neighboring neurons. Although extensive genetic data implicate the beta amyloid peptide (Aβ) in the neurodegenerative cascade ...
-
(2007)A number of psychiatric and neurodegenerative disorders, such as Alzheimer's disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced by ...
-
(2012)Alzheimer's disease (AD) is a brain disorder displaying a prevalence and impact in constant expansion. This expansive and epidemic behavior is concerning medical and public opinion while focusing efforts on its prevention ...
-
(Kluwer Academic Publishers, 1994)After the finding of the involvement of the C-terminal moieties of tubulin subunits in the interaction of MAPs, different studies have focused on the substructure of the binding domains for the different MAPs. Current ...
-
(2007)The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have ...
-
(IOS Press, 2019)The cyclin-dependent kinase 5 (CDK5) is known as an exceptional component of the CDK family, due to its characteristic regulatory pathways and its atypical roles in comparison to the classical cyclins. Despite its functional ...
-
Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism (BioMed Central, 2008)Oxidative stress has be en implicated in the progression of a number of neurodegenerative diseases, inc1uding Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out a~ in-depth ...
-
Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism (2008)Oxidative stress has been implicated in the progression of a number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out an in-depth study ...
-
(1998)We investigated the effects of the drug 14-keto-stypodiol diacetate (SDA) extracted from the seaweed product Stypopodium flabelliforme, in inhibiting the cell growth and tumor invasive behavior of DU-145 human prostate ...
-
(1995)Abstract: Microtubule‐associated proteins (MAPs) play major regulatory roles in the organization and integrity of the cytoskeletal network. Our main interest in this study was the identification and the analysis of structural ...
-
(AMER CHEMICAL SOC, 2004-03)A number of natural and synthetic flavonoids have been assessed previously with regard to their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition of cell cycle progression. On the ...
-
(2012)Alzheimer's disease (AD) diagnosis still depends on the triad of clinical, imaging and neuropsychological testing. The development of accurate, easy to use and inexpensive biological markers for AD is a long-standing ...
-
(Universisdad de Chile, 2004)La quinasa dependiente de ciclina cdk5 es un miembro atípico de la familia de las cdks, ya que no esta involucrada en los procesos que controlan el ciclo celular, pero juega un papel fundamental en el desarrollo del sistema ...
-
(1998)Cultures of cerebellar macroneurons were used to study the pattern of expression, subcellular localization, and function of the neuronal cdk5 activator p35 during laminin-enhanced axonal growth. The results obtained indicate ...
