Browsing by Author "Macho Fisher, Pilar"

Now showing items 1-8 of 8

    • Changes in total and transmural coronary blood flow induced by ethanol 
      Pescio,; Macho Fisher, Pilar; Penna, Antonello; Domenech, Cristina (1983)
      We studied the effects of ethanol on total coronary resistance and on the resistance across the left ventricular wall in the isolated empty beating heart of the dog. The coronaries were perfused with homologous fresh blood, ...
    • Effect of left intraventricular pressure on magnitude of vascular waterfall in the epicardial coronary veins 
      Domenech, Cristina; Macho Fisher, Pilar; Barros, (1990)
      Study objective: The aim was to test the hypothesis of a vascular waterfall in the epicardial veins due to compression by the left ventricular (LV) pressure. If this were so, the epicardial venous pressure should be a ...
    • Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: Possible role in ... 
      Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Exercise induces early and late myocardial preconditioning in dogs 
      Domenech Lira, Raúl; Macho Fisher, Pilar; Schwarze, Hermann; Sánchez, Gina (2002)
      Objective: We tested the hypothesis that exercise induces myocardial preconditioning in dogs. Methods: We instrumented dogs with a snare on the anterior descending coronary artery and catheters in the root of the aorta, ...
    • Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium 
      Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activation. As the ...
    • Non-ischemic myocardial preconditioning 
      Domenech Lira, Raúl; Macho Fisher, Pilar (1998)
      The reduction of infarct size produced by brief ischemic episodes prior to a sustained occlusion of a coronary artery, called ischemic preconditioning, is a well known phenomenon that occurs in several species, but its ...
    • Relative participation of adenosine and endothelium derived mediators in coronary reactive hyperemia in the dog 
      Macho Fisher, Pilar; Domenech Lira, Raúl; Penna Varela, Mario (1995)
      The metabolites that mediate coronary reactive hyperemia have not been definitely identified. Although adenosine and endothelium derived substances seem to be involved, their relative contributions have not been defined ...
    • Tachycardia preconditions infarct size in dogs: Role of adenosine and protein kinase C 
      Domenech Lira, Raúl; Macho Fisher, Pilar; Vélez, Diego; Sánchez, Gina; Liu, Xueliang; Dhalla, Naranjan (Lippincott Williams and Wilkins, 1998)
      Background - Myocardial ischemic preconditioning is a well-known phenomenon, however there is scant information in regard to nonischemic preconditioning. Methods and Results - We studied in anesthetized dogs the preconditioning ...