Browsing by Author "Mannervik, Bengt"

Now showing items 1-3 of 3

    • Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity 
      Segura Aguilar, Juan Ernesto; Mannervik, Bengt; Inzunza, José; Varshney, Mukesh; Nalvarte, Iván; Muñoz Salvatierra, Patricia Alejandra (Wolters Kluwer, 2022)
      Astrocytes protect neurons by modulating neuronal function and survival. Astrocytes support neurons in several ways. They provide energy through the astrocyte-neuron lactate shuttle, protect neurons from excitotoxicity, ...
    • Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy ... 
      Huenchuguala, Sandro; Muñoz, Patricia; Zavala, Patricio; Villa, Mónica; Urriola Cuevas, Carlos; Ahumada, Ulises; Graumann, Rebecca; Nore, Beston F.; Couve, Eduardo; Mannervik, Bengt; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Taylor and Francis Inc., 2014)
      U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
    • Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity 
      Urriola Cuevas, Carlos; Huenchuguala, Sandro; Muñoz, Patricia; Villa, Mónica; Paris Pizarro, Irmgard; Mannervik, Bengt; Segura Aguilar, Juan (Springer, 2015)
      U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) ...