Browsing by Author "Mattar, Pamela"

Now showing items 1-3 of 3

Artículo

Antilipolytic effect of calcimimetics depends on the allelic variant of calcium-sensing receptor gene ...

Reyes Jedlicki, Marcela; Rothe, Hansjörg M.; Mattar, Pamela; Shapiro, Warren B.; Cifuentes, Mariana (2012)

Calcium-sensing receptor polymorphism rs1042636 (Arg990Gly) affects the response to the calcimimetic cinacalcet, used to treat hypercalcemia in secondary hyperparathyroidism (sHPT) or parathyroid carcinoma. Carriers of ...
Artículo

Genistein activates transcription factor EB and corrects Niemann–Pick C phenotype

Argüello, Graciela; Balboa, Elisa; Tapia, Pablo J.; Castro, Juan; Yáñez, María José; Mattar, Pamela; Pulgar Tejo, Rodrigo Enrique; Zanlungo, Silvana (MDPI, 2021)

Niemann-Pick type C disease (NPCD) is a lysosomal storage disease (LSD) characterized by abnormal cholesterol accumulation in lysosomes, impaired autophagy flux, and lysosomal dysfunction. The activation of transcription ...
Artículo

Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression ...

Cifuentes, Mariana; Fuentes, Cecilia; Mattar, Pamela; Tobar, Nicolas; Hugo, Eric; Ben-Jonathan, Nira; Rojas Baechler, Cecilia; Martínez, Jorge (2010)

Obesity-associated health complications are thought to be in part due to the low-grade proinflammatory state that characterizes this disease. The calcium sensing receptor (CaSR), which is expressed in human adipose cells, ...