Browsing by Author "Meléndez, Jaime"

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    • A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo 
      Zarate, Ana María; Espinosa Bustos, Christian; Guerrero, Simón; Fierro, Angélica; Oyarzún Ampuero, Felipe; Geoffery Quest, Andrew; Di Marcotullio, Lucía; Loricchio, Elena; Caimano, Miriam; Calcaterra, Andrea; González Quiroz, Matías; Aguirre, Adam; Meléndez, Jaime; Salas, Cristian O. (MDPI, 2021)
      The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists ...
    • Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy 
      Ebensperger González, Roberto; Acevedo, Erika; Meléndez, Jaime; Corbalán, Ramón; Acevedo, Mónica; Sapag Hagar, Mario; Jalil Milad, Jorge; Lavandero González, Sergio (Academic Press Inc., 1998)
      There is evidence that insulin-like growth factor-1 (IGF-1) plays a role in the development of left ventricular hypertrophy, but it is uncertain whether cardiac IGP-1 changes before or after hypertension is established, ...