Browsing by Author "Molgó, Jordi"

Now showing items 1-12 of 12

    • Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered ... 
      Cárdenas, César; Juretic Díaz, Nevenka Militza; Bevilacqua, Jorge; García, Isaac E.; Figueroa, Reinaldo; Hartley, Ricardo; Taratuto, Ana L.; Gejman, Roger; Riveros, Nora; Molgó, Jordi; Jaimovich Pérez, Enrique (2010)
      Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) drive calcium signals involved in skeletal muscle excitation-transcription coupling and plasticity; IP3R subtype distribution and downstream events evoked by their ...
    • HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol ... 
      Paredes, Felipe; Parra, Valentina; Torrealba, Natalia; Navarro Márquez, Mario F.; Gatica, Damián; Bravo Sagua, Roberto; Troncoso, Rodrigo; Pennanen, Christian; Quiroga, Clara; Chiong Lay, Mario; Caesar, Christa; Taylor, W. Robert; Molgó, Jordi; San Martín, Alejandra; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Elsevier, 2016)
      Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
    • Inhibition of InsP3R with xestospongin B reduces mitochondrial respiration and induces selective cell death ... 
      Cruz, Pablo; Ahumada Castro, Ulises Jonas; Bustos, Galdo; Molgó, Jordi; Sauma Mahaluf, Daniela Macarena; Lovy, Alenka; Cárdenas, César (MDPI, 2021)
      T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial ...
    • The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 
      Vicencio, José Miguel; Ortíz, C.; Criollo Céspedes, Alfredo; Jones, A. W. E.; Kepp, O.; Galluzzi, Lorenzo; Joza, N.; Vitale, I.; Morselli, E.; Tailler, M.; Castedo, M.; Maiuri, M. C.; Molgó, Jordi; Szabadkai, G.; Lavandero González, Sergio; Kroemer, Guido (NATURE PUBLISHING GROUP, 2009-07)
      The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
    • Neuronal and muscular alterations caused by two wheat endosperm proteins, puroindoline-a and alpha1-purothionin, ... 
      Llanos Vidal, Paola; Henríquez Luna, Mauricio; Minic, Jasmina; Elmorjani, Khalil; Marion, Didier; Riquelme Pino, Gloria; Molgó, Jordi; Benoit, Evelyne (SPRINGER, 2004-05)
      Using the patch-clamp technique it was found that the toxicity of the two wheat endosperm proteins puroindoline-a and alpha1-purothionin probably results from the dissipation of ion concentration gradients essential ...
    • Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response ... 
      Cárdenas, César; Liberona Leppe, José; Molgó, Jordi; Colasante, Cesare; Mignery, Gregory; Jaimovich Pérez, Enrique (COMPANY OF BIOLOGISTS LTD, 2005-07-15)
      Several lines of evidence indicate that increases in nuclear Ca2+ have specific biological effects that differ from those of cytosolic Ca2+, suggesting that they occur independently. The mechanisms involved in controlling ...
    • Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced ... 
      Chiong Lay, Mario; Parra, V.; Eisner, V.; Ibarra, C.; Maldonado, C.; Criollo Céspedes, Alfredo; Bravo, R.; Quiroga, C.; Contreras, A.; Vicencio Bustamante, José; Cea, P.; Bucarey, J.; Molgó, Jordi; Jaimovich Pérez, Enrique; Hidalgo Tapia, María Cecilia; Kroemer, G.; Lavandero González, Sergio (2010)
      Hyperosmotic stress promotes rapid and pronounced apoptosis in cultured cardiomyocytes. Here, we investigated if Ca2+ signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] ...
    • Receptors and Ca2+ signals in adult skeletal muscle satellite cells in situ 
      Molgó, Jordi; Colasante, Cesare; Adams, Dany S.; Jaimovich Pérez, Enrique (SOCIEDAD BIOLOGIA CHILE, 2004)
      In this short article we review muscle satellite cell characteristics and our studies in adult rodent muscle satellite cells in situ. Using confocal laser scanning microscopy and immunocytochemistry, a high level of IP3 ...
    • Regulation of autophagy by the inositol trisphosphate receptor 
      Criollo Céspedes, Alfredo; Maiuri, M. C.; Tasdemir, E.; Vitale, I.; Fiebig, A. A.; Andrews, D.; Molgó, Jordi; Díaz, J.; Lavandero González, Sergio; Harper, F.; Pierron, G.; di Stefano, D.; Rizzuto, R.; Szabadkai, G.; Kroemer, Guido (NATURE PUBLISHING GROUP, 2007-05)
      The reduction of intracellular 1,4,5-inositol trisphosphate (IP3) levels stimulates autophagy, whereas the enhancement of IP3 levels inhibits autophagy induced by nutrient depletion. Here, we show that knockdown of the ...
    • A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and ... 
      Daneshian, Mardas; Botana, Luis M.; Dechraoui Bottein, Marie-Yasmine; Buckland, Gemma; Campàs, Mònica; Dennison, Ngaire; Dickey, Robert W.; Diogène, Jorge; Fessard, Valérie; Hartung, Thomas; Humpage, Andrew; Leist, Marcel; Molgó, Jordi; Quilliam, Michael A.; Rovida, Costanza; Suárez Isla, Benjamín; Tubaro, Aurelia; Wagner, Kristina; Zoller, Otmar; Dietrich, Daniel (Spektrum Akademischer Verlag-Springer-Verlag Gmbh, 2013)
      Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin - marine biotoxins - poses a health threat for consumers, The gold standards to assess toxins ...
    • Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ ... 
      Liberona Leppe, José; Cárdenas Matus, Julio; Reyes, Roberto; Hidalgo Tapia, Jorge; Molgó, Jordi; Jaimovich Pérez, Enrique (CHURCHILL LIVINGSTONE, 2008-09)
      Brevetoxin-3 (PbTx-3), described to increase the open probability of voltage-dependent sodium channels, caused trains of action potentials and fast oscillatory changes in fluorescence intensity of fluo-3-loaded rat skeletal ...
    • Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated ... 
      Jaimovich Pérez, Enrique; Mattei, César; Liberona Leppe, José; Cárdenas, César; Estrada Hormazábal, Manuel; Barbier, Julien; Debitus, Cécile; Laurent, Dominique; Molgó, Jordi (ELSEVIER SCIENCE BV, 2005-04-11)
      Xestospongin B, a macrocyclic bis-1-oxaquinolizidine alkaloid extracted from the marine sponge Xestospongia exigua, was highly purified and tested for its ability to block inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ ...