Browsing by Author "Muñoz, Patricia"
Now showing items 1-13 of 13
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(Bentham Science, 2016)The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...
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(SPRINGER, 2010-01-20)Abstract In previous studies, we observed that cells treated with aminochrome obtained by oxidizing dopamine with oxidizing agents dramatically changed cell morphology, thus posing the question if such morphological changes ...
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(Universidad de Chile, 2005)En esta línea, el trabajo que se expone a continuación constituye una investigación cualitativa y exploratoria, que analizará dos problemas ambientales en el ámbito local, teniendo en cuenta su dimensión política y social. ...
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(Oxford University Press, 2015)It was reported that aminochrome induces the formation of alpha synuclein (SNCA) oligomers during dopamine oxidation. We found that DT-diaphorase (NQO1) prevents the formation of SNCA oligomers in the presence of ...
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(Taylor and Francis Inc., 2014)U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
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(Springer, 2015)U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) ...
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(Elsevier, 2017)There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia ...
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(Universidad de Chile, 2005)Este proyecto es un estudio que aborda el surgimiento y desarrollo del Movimiento Ecologista/Ambientalista, desde las perspectivas teóricas de los Nuevos Movimientos Sociales. Para abordar este tipo de acción colectiva ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2004-10-01)Glutathione (GSH) constitutes the single most important antioxidant in neurons, whereas iron causes oxidative stress that leads to cell damage and death. Although GSH and iron produce opposite effects on redox cell status, ...
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(International Society for Neurochemistry,, 2014)The molecular mechanisms causing the loss of dopaminergic neurons containing neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson’s disease are still unknown. The discovery of genes ...
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(AMER CHEMICAL SOC, 2010-09)DT-Diaphorase has been proposed to play a neuroprotective role in dopaminergic neurons by preventing aminochrome neurotoxicity. There are several studies supporting this idea, but in all studies, we used dicoumarol, an ...
