Browsing by Author "Orellana Bown, Myriam"

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    • Actividad del citocromo P450 y su alteración en diversas patologías 
      Orellana Bown, Myriam; Guajardo Tobar, Viviana (SOC MEDICA SANTIAGO, 2004-01)
      Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate ...
    • Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and ... 
      Faúndez, Mario; López Muñoz, Rodrigo; Torres, Gloria; Morello Casté, Antonio; Ferreira, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Maya Arango, Juan (AMER SOC MICROBIOLOGY, 2008)
      L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
    • Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole 
      López Muñoz, Rodrigo; Faúndez, Mario; Klein, Sebastián; Escanilla, Sebastián; Torres, Gloria; Lee-Liu, Dasfne; Ferrada Parker, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Morello Casté, Antonio; Ferreira, Arturo; Maya Arango, Juan (ELSEVIER, 2010)
      Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an antiparasitic ...