Browsing by Author "Osorio Barrios, Francisco"

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    • The demethylase inhibitor GSK‑J4 limits infammatory colitis by promoting de novo synthesis of retinoic acid ... 
      Doñas, Cristian; Neira, Jocelyn; Osorio Barrios, Francisco; Carrasco, Macarena; Fernández, Dominique; Prado, Carolina; Loyola, Alejandra; Pacheco, Rodrigo; Rosemblatt Silber, Mario César (Nature, 2021)
      Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory ...
    • The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype ... 
      Doñas, Cristian; Carrasco, Macarena; Fritz, Macarena; Ríos del Prado, Carolina Alejandra; Tejón, Gabriela; Osorio Barrios, Francisco; Manríquez, Valeria; Reyes, Paz; Pacheco, Rodrigo; Bono Merino, María Rosa; Loyola, Alejandra; Rosemblatt Silber, Mario César (Academic Press, 2016)
      © 2016 The Authors As it has been established that demethylation of lysine 27 of histone H3 by the lysine-specific demethylase JMJD3 increases immune responses and thus elicits inflammation, we hypothesize that inhibition ...