Browsing by Author "Oyarzún Ampuero, Felipe"
Now showing items 1-7 of 7
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(American Chemical Society, 2019)To date, a large number of active molecules are hydrophilic and aromatic low molecular-weight drugs (HALMD). Unfortunately, the low capacity of these molecules to interact with excipients and the fast release when a ...
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(MDPI, 2021)The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists ...
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(Elsevier, 2015)The incidence of ulcers associated to type 2 diabetes mellitus (T2DM) increases every year. We introduce and explore a new mathematical algorithm to evaluate wound-healing in foot ulcers associated to T2DM. Fifteen patients ...
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(Universidad de Chile, 2017)El uso de formulaciones como los microgeles es una alternativa para vehiculizar moléculas complejas, por ejemplo, fármacos sensibles al medio externo, tóxicas o de baja biodisponibilidad. En teoría, es posible controlar ...
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(Universidad de Chile, 2017)La curcumina es un compuesto fenólico con una potente actividad biológica. Entre éstas destacan sus propiedades antioxidantes, anticancerígenas y antiinflamatorias. Esta molécula presenta además una muy baja toxicidad y ...
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(Elsevier, 2013)Here we report the development of new drug nanocarriers – named hyaluronan nanocapsules – for the intracellular delivery of hydrophobic anticancer drugs. These nanocapsules are composed of a lipid core and a shell of ...
