Browsing by Author "Pérez Acle, Tomás"

Now showing items 1-4 of 4

    • Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function 
      Jara, Oscar; Acuña, Rodrigo; García, Isaac E.; Maripillán, Jaime; Figueroa, Vania; Sáez, Juan C.; Araya Secchi, Raúl; Lagos, Carlos F.; Pérez Acle, Tomás; Berthoud, Viviana M.; Beyer, Eric C.; Martínez, Agustín D. (2012)
      To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, ...
    • Insights on the structure and stability of Licanantase: a trimeric acid-stable coiled-coil lipoprotein from ... 
      Abarca, Fernando; Gutiérrez Maldonado, Sebastián; Parada, Pilar; Martínez, Patricio; Maass Sepúlveda, Alejandro; Pérez Acle, Tomás (PeerJ, 2014)
      Licanantase (Lic) is the major component of the secretome of Acidithiobacillus thiooxidans when grown in elemental sulphur. When used as an additive, Lic improves copper recovery frombioleaching processes. However, this ...
    • Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational ... 
      González Nilo, Fernando; Pérez Acle, Tomás; Guínez Molinos, Sergio; Geraldo, Daniela A.; Sandoval, Claudia; Yévenes, Alejandro; Santos, Leonardo S.; Laurie, V. Felipe; Mendoza, Hegaly; Cachau, Raúl E. (SOC BIOLGIA CHILE, 2011)
      After the progress made during the genomics era, bioinformatics was tasked with supporting the fl ow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and ...
    • The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels 
      García, Isaac E.; Villanelo, Felipe; Contreras, Gustavo F.; Pupo, Amaury; Pinto, Bernardo I.; Contreras, Jorge E.; Pérez Acle, Tomás; Alvarez, Osvaldo; Latorre, Ramón; Martínez, Agustín D.; González, Carlos (Rockefeller University Press, 2018)
      Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, ...