Browsing by Author "Paris Pizarro, Irmgard"
Now showing items 1-20 of 23
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(2007)Four decades after L-dopa introduction to PD therapy, the cause of Parkinson's disease (PD) remains unknown despite the intensive research and the discovery of a number of gene mutations and delections in the pathogenesis ...
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(SPRINGER, 2010-01-20)Abstract In previous studies, we observed that cells treated with aminochrome obtained by oxidizing dopamine with oxidizing agents dramatically changed cell morphology, thus posing the question if such morphological changes ...
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(Springer New York LLC, 2016)© 2015, Springer Science+Business Media New York.In this study, we investigated the role of adducts formation between aminochrome and tubulin and its interference in microtubules assembly and stability in aminochrome-induced ...
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(2011)Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
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(Frontiers Media S.A., 2016)
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Copper neurotoxicity in rat substantia Nigra and striatum is dependent on DT-diaphorase inhibition (2008)The dependence of copper neurotoxicity on DT-diaphorase inhibition was suggested from results obtained from a cell line derived from substantia nigra. Therefore, the aim of this study was to evaluate whether CuSO4 neurotoxicity ...
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(BLACKWELL SCIENCE LTD, 2001-04)The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
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(Frontiers Research Foundation, 2016)
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(Universidad de Chile, 2012)La contaminación de cultivos celulares por Mollicutes es frecuente a nivel mundial y muy relevante ya que estas bacterias producen un amplio rango de alteraciones metabólicas y cromosómicas en las células afectadas que ...
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(AMER CHEMICAL SOC, 2005-03)We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...
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(Springer New York LLC, 2010)
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(Taylor and Francis Inc., 2014)U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
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(Springer, 2015)U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) ...
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(Elsevier, 2017)There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia ...
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(BLACKWELL PUBLISHING LTD, 2005-03)The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both ...
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(Taylor & Francis Ltd, 2001-05-04)Monoamine oxidase-A (MAO-A) (amiflamine (AMF) and 4-methylthioamphetamine (MTA)) and MAO-B (Ldeprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHTcells derived from adult rat ...
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(2012)We tested the hypothesis that both VMAT-2 and DT-diaphorase are an important cellular defense against aminochrome-dependent neurotoxicity during dopamine oxidation. A cell line with VMAT-2 and DT-diaphorase over-expressed ...
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(ACADEMIC PRESS INC, 2001-05-25)The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...
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(International Society for Neurochemistry,, 2014)The molecular mechanisms causing the loss of dopaminergic neurons containing neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson’s disease are still unknown. The discovery of genes ...
