Browsing by Author "Parra, Eduardo"
Now showing items 1-7 of 7
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Parra, Eduardo; Gutiérrez, Luis; Ferreira Parker, Jorge (Spandidos Publ. Ltd., 2016)The Tax protein of human T cell leukemia virus type 1 plays a major role in the pathogenesis of adult T cell leukemia (ATL), an aggressive neoplasia of CD4(+) T cells. In the present study, we investigated whether the ...
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Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (Spandidos Publications, 2014)The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARFlevels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification ...
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Parra, Eduardo; Ortega, Arnaldo; Sáenz Iturriaga, Leonardo Enrique (2009)The inhibitory effect of a specific small EGR-1 interfering RNA (siRNA) on cell proliferation and the expression of EGR-1 in human prostate carcinoma cell lines PC-3 and LNCaP was investigated. To knockdown Egr-1 expression, ...
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Parra, Eduardo; Ferreira Parker, Jorge; Sáenz Iturriaga, Leonardo Enrique (2011)Previous studies suggest that the effects of Egr-1 on tumorigenesis are critically dependent on the levels of Egr-1 and the cellular context. For this reason, we examined the effects of blocking the Egr-1 activity by a ...
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Cortés, Leonel A.; Castro, Lorena; Pesce Reyes, Bárbara; Maya Arango, Juan; Ferreira, Jorge; Castro Castillo, Vicente; Parra, Eduardo; Jara, José A.; López Muñoz, Rodrigo (Public Library Science, 2015)Chagas disease is one of the most neglected tropical diseases in the world, affecting nearly 15 million people, primarily in Latin America. Only two drugs are used for the treatment of this disease, nifurtimox and benznidazole. ...
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Urra, Félix A.; Martínez Cifuentes, Maximiliano; Pavani, Mario; Lapier, Michel; Jaña Prado, Fabián; Parra, Eduardo; Maya Arango, Juan; Pessoa Mahana, Hernán; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Elsevier, 2013)Tumor cells present a known metabolic reprogramming, which makes them more susceptible for a selective cellular death by modifying its mitochondrial bioenergetics. Anticancer action of the antioxidant 9,10- dihydroxy-4 ...
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Jaña, Fabián; Faini, Francesca; Lapier, Michel; Pavani, Mario; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Jara, José; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2013)Changes in mitochondrial ATP synthesis can affect the function of tumor cells due to the dependence of the first step of glycolysis on mitochondrial ATP. The oxidative phosphorylation (OXPHOS) system is responsible for ...