Browsing by Author "Pinto, Mauricio P."

Now showing items 1-5 of 5

    • A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict ... 
      Córdova Delgado, Miguel Angel; Bravo, María Loreto; Cumsille, Elisa; Hill, Charlotte N.; Muñoz Medel, Matías; Pinto, Mauricio P.; Retamal, Ignacio N.; Lavanderos, María; Miquel, Juan Francisco; Rodríguez Fernández, María (BMC, 2021)
      Background: Fluoropyrimidine plus platinum chemotherapy remains the standard first line treatment for gastric cancer (GC). Guidelines exist for the clinical interpretation of four DPYD genotypes related to severe ...
    • Case report: molecular features and treatment options for small bowel adenocarcinoma 
      Córdova Delgado, Miguel Angel; Pizarro, Gonzalo; Pinto, Mauricio P.; Herrera, María Elisa; Garrido, Marcelo (Frontiers Media, 2021)
      Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main ...
    • Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa 
      Lange, Soledad; Gonzalez, Ibeth; Pinto, Mauricio P.; Arce, Maximiliano; Valenzuela, Rodrigo; Aranda, Evelyn; Elliot, Matias; Alvarez, Marjorie; Henriquez, Soledad; Velasquez, Ethel V.; Orge, Felipe; Oliva, Barbara; Gonzalez, Pamela; Villalon, Manuel; Cautivo, Kelly M.; (Wiley-Liss Inc., 2014)
      Knockout models have shown that the coagulation system has a role in vascular development and angiogenesis. Herein, we report for the first time that zymogen FX and its active form (FXa) possess anti-angiogenic properties. ...
    • Mutational landscape and actionable target rates on advanced stage refractory cancer patients: a multicenter ... 
      Córdova Delgado, Miguel Angel; Pinto, Mauricio P.; Regonesi, Carlos; Cereceda, Luis; Reyes, José Miguel; Itriago, Laura; Majlis, Alejandro; Rodríguez, Pablo; Fassler, André; Mahave, Mauricio; León, María Elisa; Gallardo, Jorge; Rodríguez Z., María Paz; Berkovits, Alejandro; Manque, Patricio; Ríos, Juvenal A.; García Bloj, Benjamín; Garrido, Marcelo (MDPI, 2022)
      Major advances in sequencing technologies and targeted therapies have accelerated the incorporation of oncology into the era of precision medicine and "biomarker-driven" treatments. However, the impact of this approach on ...
    • Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, ... 
      Córdova Delgado, Miguel Angel; Pinto, Mauricio P.; Pizarro, Gonzalo; Koch, Elard; Vargas, Cristian; Hernández, Mauricio; Nourdin, Guillermo; Saldivia, Pablo; Rodríguez Z., María Paz; Berkovits, Alejandro; Manque, Patricio; Rios, Juvenal A.; Garcia-Bloj, Benjamín; Garrido, Marcelo (AME Publishing Company, 2022)
      Background: Early-onset gastric cancers (EOGC) are poor prognosis hard-to treat malignancies that affect young individuals (<45 years old). Case Description: Herein we describe the case of a 26-year-old female EOGC patient ...