Browsing by Author "Quiñones Sepúlveda, Luis Abel"

Now showing items 1-15 of 15

    • Análisis farmacogenético retrospectivo de una paciente pediátrica en tratamiento anticoagulante: caso clínico 
      Cavieres, Mirta; Suárez, Marcelo; Verón, Gabriel; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel (Inst Nacional Salud, Colombia, 2021)
      We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, ...
    • Análisis y consideraciones técnicas acerca de dispositivos intrauterinos de levonorgestrel para la evaluación ... 
      Quiñones Sepúlveda, Luis Abel; Salas Hernández, Aimeé V. (Elsevier, 2021)
      Levonorgestrel hormonal intrauterine systems are safe and effective contraceptive methods. Like conventional drugs, once the patent expires, health regulatory authorities can approve the registration of similar products. ...
    • Effect of CYP3A4, CYP3A5, MDR1 and POR genetic polymorphisms in immunosuppressive treatment in chilean ... 
      Contreras Castillo, Stephania Nichols; Plaza, Anita; Stojanova, Jana; Navarro, Gustavo; Carmona, Rodolfo; Corvalán, Fernando; Cerpa, Leslie; Sandoval, Christopher; Muñoz, Daniel; Leiva, Marina; Castañeda Sepúlveda, Luis Eduardo; Farías, Nayaret; Álvarez, Carolina; Llull Morchio, Gabriel Eduardo; Mezzano, Sergio; Ardiles, Leopoldo; Varela Figueroa, Nelson Miguel; Rodríguez, María S.; Flores, Claudio; Cayún, Juan Pablo; Krall Opazo, Paola Margarita; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)
      Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and ...
    • Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population 
      Alvarado, Ángel Tito; Muñoz, Ana María; Saravia Bartra, María; Valderrama Wong, Milton; González Aristegui, Daniela; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel; Bendezú, María Rocío; García, Jorge Antonio; Loja Herrera, Berta (Pensoft, 2021)
      The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) ...
    • Frequency of CYP2D6*3 and *4 and metabolizer phenotypes in three mestizo Peruvian populations 
      Alvarado, Ángel T.; Ybáñez Julca, Roberto; Muñoz, Ana María; Tejada Bechi, César; Cerro, Roberto; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel; Alvarado, César André; Alvarado, Erick; Bendezú, María R.; García, Jorge A. (Pensoft Publishers, Bulgaria, 2021)
      Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 and 0.051 for CYP2D6*4. The percentages of ...
    • Impacto de la atención farmacéutica en la calidad del tratamiento con acenocumarol en pacientes con fibrilación ... 
      Leal, Bryan; Torres, Héctor; Roco, Angela; Román, Ricardo; Rojo, Mario; Nieto, Elena; Quiñones Sepúlveda, Luis Abel (Soc. Médica Santiago, 2021)
      Background: Vitamin K antagonists such as acenocoumarol and warfarin are usually indicated for the treatment of Atrial Fibrillation (AF). The Therapeutic Range Time (TRT) is a quality of treatment indicator. Values greater ...
    • In silico analyses of immune system protein interactome network, single-cell RNA sequencing of human tissues, ... 
      López Cortés, Andrés; Guevara Ramírez, Patricia; Kyriakidis, Nikolaos C.; Barba Ostria, Carlos; León Cáceres, Ángela; Guerrero, Santiago; Ortiz Prado, Esteban; Munteanu, Cristian R.; Tejera, Eduardo; Cevallos Robalino, Doménica; Gómez Jaramillo, Ana María; Simbaña Rivera, Katherine; Granizo Martínez, Adriana; Pérez M., Gabriela; Moreno, Silvana; García Cárdenas, Jennyfer M.; Zambrano, Ana Karina; Pérez Castillo, Yunierkis; Cabrera Andrade, Alejandro; Puig San Andrés, Lourdes; Proaño Castro, Carolina; Bautista, Jhommara; Quevedo, Andreina; Varela Figueroa, Nelson Miguel Edgardo; Quiñones Sepúlveda, Luis Abel; Paz y Miño, César (Frontiers Media, 2021)
      Background: There is pressing urgency to identify therapeutic targets and drugs that allow treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune system protein interactome network, ...
    • NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with ... 
      González Hormazábal, Patricio; Peláez, Diana; Musleh Katan, Maher Elías; Bustamante, Marco; Stambuk Mayorga, Juan Antonio; Pisano, Raúl; Valladares Hernández, Héctor; Lanzarini Sobrevía, Enrique Giovani; Chiong, Héctor; Suazo Sanhueza, José Lorenzo; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel Edgardo; Castro, Gonzalo; Jara Sosa, Lilian Elena; Berger, Zoltan (Sociedad de Biología de Chile, 2021)
      BackgroundHelicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against ...
    • Pharmacogenetic associations between atazanavir/UGT1A1*28 and efavirenz/rs3745274 (CYP2B6) account for ... 
      Poblete Astroza, Daniela Lorena; Bernal, Fernando; Llull Morchio, Gabriel Eduardo; Archiles Olivares, Sebastián Gabriel; Vásquez, Patricia; Chanqueo Cornejo, Leonardo Andrés; Soto, Nicole; Lavanderos de Paz, María Angélica; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel Edgardo (Frontiers Media, 2021)
      Background: Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, and atazanavir (ATV), a protease inhibitor, are drugs widely used in antiretroviral therapy (ART) for people living with HIV. These drugs have ...
    • Pharmacogenetics–based preliminary algorithm to predict the incidence of infection in patients receiving ... 
      Martínez Olguín, Matías Fernando; Alveal, Enzo; Soto, Tomás Gonzalo; Bustamante, Eva I.; Ávila Oesterle, Fernanda; Bangdiwala, Shrikant Ishver; Flores, Ivonne; Monterrosa, Claudia; Morales, Ricardo; Varela Figueroa, Nelson Miguel Edgardo; Fohner, Alison E.; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)
      Introduction: Infections in hematological cancer patients are common and usually lifethreatening; avoiding them could decrease morbidity, mortality, and cost. Genes associated with antineoplastics’ pharmacokinetics or ...
    • Preliminary pharmacogenomic-based predictive models of tamoxifen response in hormone-dependent chilean ... 
      Miranda, Carla; Galleguillos, Macarena; Torres, Roberto; Tardon, Karla; Cáceres Lillo, Dante; Lee, Kuen-shiou; Redal, María A.; Varela, Nelson M.; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)
      Tamoxifen (TAM), a selective oestrogen receptor modulator, is one of the most used treatments in oestrogen receptor-positive (ER+) early and metastatic breast cancer (BC) patients. The response to TAM has a high degree of ...
    • Pulmonary inflammatory response in lethal COVID-19 reveals potential therapeutic targets and drugs in phases ... 
      López Cortés, Andrés; Guerrero, Santiago; Ortiz Prado, Esteban; Yumiceba, Verónica; Vera Guapi, Antonella; León Cáceres, Ángela; Simbaña Rivera, Katherine; Gómez Jaramillo, Ana María; Echeverría Garcés, Gabriela; García Cárdenas, Jennyfer M.; Guevara Ramírez, Patricia; Cabrera Andrade, Alejandro; Puig San Andrés, Lourdes; Cevallos Robalino, Doménica; Bautista, Jhommara; Armendáriz Castillo, Isaac; Pérez Villa, Andy; Abad Sojos, Andrea; Ramos Medina, María José; León Sosa, Ariana; Abarca, Estefanía; Pérez Meza, Álvaro A.; Nieto Jaramillo, Karol; Jácome, Andrea V.; Morillo, Andrea; Arias Erazo, Fernanda; Fuenmayor González, Luis; Quiñones Sepúlveda, Luis Abel; Kyriakidis, Nikolaos C. (Frontiers Media, 2022)
      Background: It is imperative to identify drugs that allow treating symptoms of severe COVID-19. Respiratory failure is the main cause of death in severe COVID-19 patients, and the host inflammatory response at the lungs ...
    • Role of mir-92a-3p in the expression of genes ofchemoresistance to fluorouracil and oxaliplatin viaactivation ... 
      Escalante Escalante, Paula Isabel (Universidad de Chile, 2022)
      El cáncer colorrectal (CCR) es el segundo más diagnosticado en Chile y el mundo. El tratamiento de primera línea del CCR metastásico consiste en la asociación de 5-fluorouracilo (5-FU) y oxaliplatino (L-OHP), conocido ...
    • Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV- 2 infectious individuals 
      Young, Rodrigo M.; Solis, Camila J.; Barriga Fehrman, Andrés; Abogabir, Carlos; Thadani, Álvaro R.; Labarca, Mariana; Bustamante, Eva; Tapia, Cecilia V.; Sarda, Antonia G.; Sepúlveda, Francisca; Pozas, Nadia; Cerpa, Leslie C; Lavanderos, María A.; Varela Figueroa, Nelson Miguel Edgardo; Santibáñez, Álvaro; Sandino, Ana M.; Reyes López, Felipe; Dixon, Garth; Quiñones Sepúlveda, Luis Abel (Elife Sciences Publications, 2021)
      The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could ...
    • Variantes genéticas asociadas al metabolismo del arsénico, su efecto sobre el estrés oxidativo y la función ... 
      Torres Inostroza, Valentina Andrea (Universidad de Chile, 2024)
      La exposición al arsénico es catalogada como una gran amenaza para la salud pública, debido a los efectos nocivos causados por este metaloide, que van desde la hiperpigmentación, enfermedades cardiovasculares y hasta la ...