Browsing by Author "Rivera Meza, Mario"
Now showing items 1-20 of 26
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(Frontiers Media S.A., 2017)© 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the ...
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(Elsevier Ltd, 2019)© 2018 Elsevier Ltd A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic ...
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(2013)Background: Animals that have chronically consumed alcohol and are subsequently deprived of it markedly increase their intake above basal levels when access to alcohol is reinstated. Such an effect, termed the alcohol ...
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(Universidad de Chile, 2018)El efecto reforzante del etanol contribuye a la generación de dependencia. Para que el etanol sea reforzante se requiere que este se metabolice a acetaldehído en el cerebro, el cual activa neuronas dopaminérgicas en el ...
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(Oxford Univ Press, 2015)
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(Wiley-Blackwell, 2016)Background: A number of studies have shown that acetaldehyde synthesized in the brain is necessary to induce ethanol (EtOH) reinforcement in naive animals (acquisition phase). However, after chronic intake is achieved ...
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(Universidad de Chile, 2020)La rata UChB es un modelo animal de alcoholismo caracterizado por su alto consumo voluntario de etanol, el cual se verifica bajo el paradigma de libre acceso a dos botellas (agua y alcohol 10%). Sin embargo, el consumo ...
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(2011)Background: While the molecular entity responsible for the rewarding effects of virtually all drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest that the rewarding effects of alcohol ...
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(Universidad de Chile, 2022)El alcohol es una sustancia psicoactiva con propiedades tóxicas y productoras de dependencia. La OMS estima que 3 millones de muertes anuales son atribuibles al consumo de alcohol. El tratamiento farmacológico actual del ...
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(Universidad de Chile, 2021)La adicción al alcohol u opioides son enfermedades crónicas con consecuencias negativas tanto para el paciente como su entorno familiar y social. A nivel global, el consumo crónico de alcohol es causante de la muerte de ...
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(Wiley-Blackwell, 2015)This review analyzes literature that describes the behavioral effects of 2 metabolites of ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and dopamine) generated in the brain. These ...
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(Nature Publishing Group, 2019)Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
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(FRONTIERS RESEARCH FOUNDATION, 2013-07-08)Ethanol is metabolized into acetaldehyde mainly by the action of alcohol dehydrogenase in the liver, while mainly by the action of catalase in the brain. Aldehyde dehydrogenase-2 metabolizes acetaldehyde into acetate in ...
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(Society for the Study of Addiction, 2014)Previous studies suggest that acetaldehyde generated from ethanol in the brain is reinforcing. The present studies tested the feasibility of achieving a long-term reduction of chronic and post-deprivation binge ethanol ...
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(2010)Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it ...
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(Blackwell Publishing Ltd, 2019)(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
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(Research Society on Alcoholism, 2014)Background: A number of studies have shown that ethanol (EtOH) activates dopamine neurocircuitries and is self-administered into the ventral tegmental area (VTA) of the rat brain. In vitro and in silico studies have ...
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(Oxford University Press, 2015)
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(Universidad de ChileCyberDocs, 2009)El alcoholismo es una de las adicciones de mayor prevalencia en el mundo. Sin embargo, se ha visto que la presencia de ciertos polimorfismos en los genes de las enzimas que metabolizan el etanol, son capaces de proteger ...
