Browsing by Author "Rojas, Diego A."

Now showing items 1-5 of 5

    • Endogenous overexpression of an active phosphorylated form of DNA polymerase beta under oxidative stress ... 
      Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado Maldonado, Edio (Public Library Science, 2018)
      Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria ...
    • Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the ... 
      Maldonado Maldonado, Edio; Rojas, Diego A.; Moreira Ramos, Sandra; Urbina, Fabiola; Miralles, Vicente J.; Solari Illescas, Aldo; Venegas Hermosilla, Juan Antonio (Springer, 2015)
      Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major parasitic disease that affects millions of people in America. However, despite the high impact of this disease on human health, no effective and ...
    • The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A 
      Rivas, Solange; Armisen Yáñez, Ricardo; Rojas, Diego A.; Maldonado Maldonado, Edio; Huerta, Hernán; Tapia, Julio C.; Espinoza, Jaime; Colombo, Alicia; Michea Acevedo, Luis; Hayman, Michael J.; Marcelain Cubillos, Katherine (Wiley & Sons, 2016)
      Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it ...
    • T. cruzi DNA polymerase beta (Tcpol beta) is phosphorylated in vitro by CK1, CK2 and TcAUK1 leading to the ... 
      Maldonado Maldonado, Edio Luis; Rojas, Diego A.; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo (Public Library Science, 2021)
      The unicellular protozoan Trypanosoma cruzi is the causing agent of Chagas disease which affects several millions of people around the world. The components of the cell signaling pathways in this parasite have not been ...
    • The catalytic subunit of schizosaccharomyces pombe CK2 (Cka1) negatively regulates RNA polymerase II ... 
      Rojas, Diego A.; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo; Maldonado Maldonado, Edio Luis (MDPI, 2022)
      Positive cofactor 4 (PC4) is a transcriptional coactivator that plays important roles in transcription and DNA replication. In mammals, PC4 is phosphorylated by CK2, and this event downregulates its RNA polymerase II ...