Browsing by Author "Roth Metcalfe, Alejandro Darío"

Now showing items 1-10 of 10

    • A Proteome Map of Axoglial Specializations Isolated and Purified from Human Central Nervous System 
      Dhaunchak, Ajit S.; Huang, Jeffrey K.; De Faria Junior, Omar; Roth Metcalfe, Alejandro Darío; Pedraza, Liliana; Antel, Jack P.; Bar-Or, Amit; Colman, David R. (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2010-09-09)
      Compact myelin, the paranode, and the juxtaparanode are discrete domains that are formed on myelinated axons. In humans, neurological disorders associated with loss of myelin, including Multiple Sclerosis, often also ...
    • Caracterización de la expresión de Septina 8 en sistema nervioso central y periférico 
      Bodaleo Torres, Felipe Jose (Universisdad de Chile, 2015)
      Las Septinas son una familia de proteínas GTPasas citoplasmaticas ampliamente distribuidas entre eucariontes y que presentan un alto porcentaje de identidad entre ellas. La presencia de Septina 8 (SEPT8) en proteoma de ...
    • Fatty acid composition of Drosophila photoreceptor light-sensitive microvilli 
      Muñoz, Yorka; Fuenzalida, Karen; Bronfman, Miguel; Gatica Rossi, Héctor; Sepúlveda, Marcelo; Bacigalupo Vicuña, Juan; Roth Metcalfe, Alejandro Darío; Delgado Arriagada, Ricardo (2013)
      Phototransduction, the mechanism underlying the electrical response to light in photoreceptor cells, has been thoroughly investigated in Drosophila melanogaster, an essential model in signal transduction research. These ...
    • Functional Consequences of Neuromyelitis Optica-IgG Astrocyte Interactions on Blood-Brain Barrier Permeability ... 
      Vincent, Thierry; Saikali, Philippe; Cayrol, Romain; Roth Metcalfe, Alejandro Darío; Bar-Or, Amit; Prat, Alexandre; Antel, Jack P. (The American Association of Immunologists, 2008)
      Autoantibody neuromyelitis optica-IgG (NMO-IgG) recognizing aquaporin-4 (AQP4) is implicated as playing a central role in the physiopathology of NMO. The aim of this in vitro-based study was to characterize functional ...
    • Identification of Tmem10/Opalin as an Oligodendrocyte Enriched Gene Using Expression Profiling Combined ... 
      Golan, Neev; Adamsky, Konstantin; Kartvelishvily, Elena; Brockschnieder, Damian; Möbius, Wiebke; Spiegel, Ivo; Roth Metcalfe, Alejandro Darío; Thomson, Christine; Rechavi, Gideon; Peles, Elior (WILEY-LISS, 2008-06-20)
      Oligodendrocytes form an insulating multilamellar structure of compact myelin around axons, which allows efficient and rapid propagation of action potentials. However, little is known about the molecular mechanisms ...
    • The Isthmic Nuclei Providing Parallel Feedback Connections to the Avian Tectum Have Different Neurochemical ... 
      González Cabrera, Cristian; Garrido Charad, Florencia; Roth Metcalfe, Alejandro Darío; Marín, Gonzalo (Wiley-Blackwell, 2015)
      Retinal inputs to the optic tectum (TeO) triggered by moving stimuli elicit synchronized feedback signals from two isthmic nuclei: the isthmi parvocelullaris (Ipc) and isthmi semilunaris (SLu). Both of these nuclei send ...
    • Septin 7 - Actin cross-organization is required for axonal association of Schwann cells 
      Roth Metcalfe, Alejandro Darío; Liazoghli, Dalinda; Pérez de Arce, Felipe; Colman, David R. (2013)
      Myelin sheaths present two distinct domains: compacted myelin spirals and fl anking non-compacted cytoplasmic channels, where lipid and protein segregation is established by unknown mechanisms. Septins, a conserved family ...
    • Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation 
      Falcón Urrutia, Paulina; Carrasco, Carlos M.; Lois, Pablo; Palma, Verónica; Roth Metcalfe, Alejandro Darío (Public Library Science, 2015)
      Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-Ra, are ...
    • Substrate Micropatterning as a New in Vitro Cell Culture System to Study Myelination 
      Liazoghli, Dalinda; Roth Metcalfe, Alejandro Darío; Thostrup, Peter; Colman, David R. (AMER CHEMICAL SOC, 2012-02)
      Myelination is a highly regulated developmental process whereby oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system ensheathe axons with a multilayered concentric membrane. ...
    • TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating ... 
      de Faria, Omar; Dhaunchak, Ajit S.; Kamen, Yasmine; Roth Metcalfe, Alejandro Darío; Kuhlmann, Tanja; Colman, David R.; Kennedy, Timothy E. (Nature Publishing Group, 2019)
      Oligodendrocyte precursor cells (OPCs) differentiate during postnatal development into myelin-forming oligodendrocytes, in a process distinguished by substantial changes in morphology and the onset of myelin gene expression. ...