Browsing by Author "Sánchez, Gina"

Now showing items 1-16 of 16

    • Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB ... 
      Kemmerling Weis, Ulrike; Muñoz Dimitrov, Pablo; Müller, Marioly; Sánchez, Gina; Aylwin Ostale, María de la Luz; Klann, Eric; Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (2007)
      Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
    • Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy 
      Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces ... 
      Barrientos Briones, Genaro; Llanos Vidal, Paola; Hidalgo Tapia, Jorge; Bolaños, Pura; Caputo, Carlo; Riquelme, Alexander; Sánchez, Gina; Quest, Andrew F. G.; Hidalgo Tapia, María Cecilia (Frontiers Research Foundation, 2015)
      Cholesterol and caveolin are integral membrane components that modulate the function/location of many cellular proteins. Skeletal muscle fibers, which have unusually high cholesterol levels in transverse tubules, express ...
    • Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion ... 
      Ibacache Figueroa, Mauricio; Sánchez, Gina; Gálvez, Felipe; Pedrozo Cibils, Zully; Humeres Martínez, Claudio; Echevarría, Ghislaine; Duaso, Juan; Hassi, Mario; García Nannig, Lorena; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2012-04)
      Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an alpha(2)-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ...
    • Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent ... 
      Riquelme, Jaime; Westermeier, Francisco; Hall, Andrew R.; Vicencio, Jose; Pedrozo Cibils, Zully; Ibacache, Mauricio; Fuenzalida, Barbara; Sobrevia, Luis; Davidson, Sean M.; Yellon, Derek M.; Sánchez, Gina; Lavandero González, Sergio (Elsevier, 2016)
      The alpha2-adrenergic receptor agonist Dexmedetomidine (Dex) is a sedative medication used by anesthesiologists. Dex protects the heart against ischemia-reperfusion (IR) and can also act as a preconditioning mimetic. The ...
    • Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning? 
      Domenech Lira, Raúl; Sánchez, Gina; Donoso Laurent, Paulina; Parra Morales, Víctor; Macho Fisher, Pilar (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2003-12)
      We have previously demonstrated that brief episodes of tachycardia prior to a prolonged occlusion of a coronary artery, followed by reperfusion, substantially reduce the infarct size. Adenosine receptors and mitochondrial ...
    • Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium 
      Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activation. As the ...
    • FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes 
      Oyarzún, Alejandra P.; Westermeier, Francisco; Pennanen, Christian; López Crisosto, Camila; Parra, Valentina; Sotomayor Flores, Cristian; Sánchez, Gina; Pedrozo Cibils, Zully; Troncoso Cotal, Rodrigo; Lavandero González, Sergio (Elsevier, 2015)
      Aim: FK866 is an inhibitor of the NAD(+) synthesis rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and ...
    • Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex 
      Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)
      Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
    • Nitric oxide synthase activity in brain tissues from llama fetuses submitted to hypoxemia 
      Galleguillos, Marco; Valenzuela Pedevila, María Antonieta; Riquelme González, Raquel; Sanhueza, Emilia M.; Sánchez, Gina; Figueroa, Jorge P.; Llanos Mansilla, Jorge (ELSEVIER SCIENCE INC, 2001-06)
      The fetal llama (Lama glama; a species adapted to live in chronic hypoxia in the highlands of the Andes) did not increase cerebral blood flow and reduce the brain oxygen uptake during hypoxemia. Although nitric oxide (NO) ...
    • Participación de Miro1 en hipertrofia en cardiomiocitos de rata neonata 
      Conejeros Vásquez, Carolina (Universidad de Chile, 2017)
      La hipertrofia cardiaca es una respuesta adaptativa del corazón frente a situaciones de sobrecarga de trabajo, la cual funciona inicialmente como un mecanismo compensatorio. Sin embargo, la hipertrofia sostenida en el ...
    • S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels 
      Aracena Parks, Paula; Sánchez, Gina; Donoso Laurent, Paulina; Hamilton, Susan L.; Hidalgo Tapia, María Cecilia (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-31)
      We have analyzed the effects of the endogenous redoxactive agents S-nitrosoglutathione and glutathione disulfide, and the NO donor NOR-3, on calcium release kinetics mediated by ryanodine receptor channels. Incubation of ...
    • The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury 
      Salas, Margarita A.; Valverde, Carlos A.; Sánchez, Gina; Said, Matilde; Rodríguez, Jesica S.; Portiansky, Enrique L.; Kaetzel, Marcia A.; Dedman, John R.; Donoso Laurent, Paulina; Kranias, Evangelia G.; Mattiazzi, Alicia (ELSEVIER, 2010)
      Ca2+-calmodulin-dependent protein kinase II (CaMKII) plays an important role mediating apoptosis/ necrosis during ischemia-reperfusion (IR). We explored the mechanisms of this deleterious effect. Langendorff perfused rat ...
    • Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium 
      Donoso Laurent, Paulina; Finkelstein Muñoz, José Pablo; Montecinos, Luis; Said, Matilde; Sánchez, Gina; Vittone, Leticia; Bull Simpfendorfer, Ricardo (Elsevier, 2014)
      The response of ryanodine receptor (RyR) channels to cytoplasmic free calcium concentration ([Ca2+]) is redox sensitive. Here, we report the effects of a mild oxidative stress on cardiac RyR (RyR2) channels in ...
    • Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle 
      Sánchez, Gina; Pedrozo Cibils, Zully; Domenech Lira, Raúl; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2005-12)
      We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning. Among other effects, tachycardia increases calcium release rates in microsomal fractions enriched in sarcoplasmic ...
    • A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine ... 
      Hidalgo Tapia, María Cecilia; Sánchez, Gina; Barrientos, Genaro; Aracena Parks, Paula (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-09-08)
      We report here the presence of an NADPH oxidase (NOX) activity both in intact and in isolated transverse tubules and in triads isolated from mammalian skeletal muscle, as established by immunochemical, enzymatic, and ...