Browsing by Author "Sánchez Valdéz, Fernando J."

Now showing items 1-3 of 3

Artículo

Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease

Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Ferreira, Arturo; Basombrío, Miguel Ángel (Expert Reviews, 2014)

Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. This illness is now becoming global, mainly due to congenital transmission, and so far, there are no prophylactic or ...
Artículo

A monoallelic deletion of the TcCRT gene increases the attenuation of a cultured trypanosoma cruzi strain, ...

Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Ramírez Toloza, Galia; Uncos, Alejandro D.; Zago, M. Paola; Cimino, Rubén O.; Cardozo, Rubén M.; Marco, Jorge D.; Ferreira Vigouroux, Luis Arturo; Basombrío, Miguel Angel (PLOS Neglected Tropical Diseases, 2014-02)

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite ...
Artículo

Trypanosoma cruzi carrying a monoallelic deletion of the calreticulin (TcCRT) gene are susceptible to ...

Sánchez Valdéz, Fernando J.; Pérez Brandán, Cecilia; Zago, M. Paola; Labriola, Carlos; Ferreira, Arturo; Basombrío, Miguel Ángel (2013-03)

Trypanosoma cruzi calreticulin (TcCRT) can hijack complement C1, mannan-binding lectin and ficolins from serum thus inhibiting the classical and lectin complement pathway activation respectively. To understand the in ...