Browsing by Author "Salazar Onfray, Flavio"

Now showing items 1-20 of 36

    • A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class ... 
      Kurte, Mónica; López, Mercedes; Aguirre, Adam; Escobar, Alejandro; Aguillón Gutiérrez, Juan Carlos; Charo, Jehad; Larsen, Christian G.; Kiessling, Rolf; Salazar Onfray, Flavio (American Association of Immunologists, 2004)
      Tumor cells treated with IL-10 were shown to have decreased, but peptide-inducible expression of MHC class I, decreased sensitivity to MHC class I-restricted CTL, and increased NK sensitivity. These findings could be ...
    • A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ ... 
      López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Caracterización de la migración de linfocitos T activados por células presentadoras de antígenos tumorales 
      Avalos Carrasco, Ignacio Patricio (Universisdad de Chile, 2015)
      El melanoma es el cáncer de piel con mayor mortalidad y uno de los canceres que progresivamente ha aumentado su incidencia tanto en Chile como en el mundo. Debido a que las terapias convencionales contra este cáncer son ...
    • Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph ... 
      Oyarce, César; Cruz Gómez, Sebastián; Gálvez Cancino, Felipe Ignacio; Vargas, Pablo; Moreau, Hélène D.; Díaz Valdivia, Natalia; Díaz, Jorge; Salazar Onfray, Flavio; Pacheco, Rodrigo; Lennon Duménil, Ana María; Quest, Andrew F. G.; Lladser, Álvaro (Frontiers Media, 2017)
      Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the ...
    • Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune ... 
      Escobar, A.; López, M.; Serrano, A.; Ramirez, M.; Pérez, C.; Aguirre, A.; González, R.; Alfaro, J.; Larrondo, M.; Fodor, M.; Ferrada, C.; Salazar Onfray, Flavio (2005)
      Dendritic cell (DC)-based therapy has proved to be effective in patients with a variety of malignancies. However, an optimal immunization protocol using DCs and the best means for delivering antigens has not yet been ...
    • Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory ... 
      Falcón Beas, Cristián; Tittarelli, Andrés; Mora-Bau, Gabriela; Tempio, Fabián; Pérez Núñez, Claudio; Hevia, Daniel; Behrens, Carolina; Flores, Iván; Falcón-Beas, Felipe; Garrido, Paola; Ascui, Gabriel; Pereda, Cristián; González, Fermín E.; Salazar Onfray, Flavio; López, Mer (Elsevier GmbH, 2019)
      Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
    • Estudio de la participación de gap junctions en la activación de linfocitos T CD8+ mediante la validación ... 
      Navarrete Sánchez, Mariela Ivonne (Universidad de Chile, 2018)
      Las Gap Junctions (GJs) son clústers de canales intercelulares localizados en la membrana plasmática que permiten la comunicación directa entre células adyacentes. Cada canal GJ está compuesto por 2 hemicanales hexaméricos ...
    • Estudio del rol de conexina 43 en la sinapsis inmunológica citolítica entre linfocitos t citotóxicos y ... 
      Hoffmann Vega, Francisca Alejandra (Universidad de Chile, 2018)
      El desarrollo de una respuesta inmune anti-tumoral requiere de la comunicación entre diferentes células del sistema inmune, así como del reconocimiento de la célula tumoral. Una vez que los Linfocitos T Citotóxicos (CTL) ...
    • Expresión constitutiva e inducible del receptor de melanocortina 1 (MC1R) en melanoma ocular maligno 
      Pereda Ramos, Cristian Javier (Universisdad de Chile, 2006)
      El melanoma ocular es un tumor altamente maligno y el mas común de los oculares en individuos adultos. A diferencia del melanoma cutáneo, el melanoma uveal presenta distintos niveles de expresión de marcadores de melanoma. ...
    • Expresión de antígenos tumorales y su correlación por estadios en tejidos de cáncer de vesícula biliar 
      Barría Catricura, Omar André (Universidad de Chile, 2018)
      El cáncer de vesícula biliar (CVB) es una enfermedad poco frecuente a nivel mundial, no obstante, países como India, Japón y Chile poseen una elevada tasa de incidencia. En nuestro país, el CVB representa una de las ...
    • Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and ... 
      Araya López, Héctor; Sepulveda, Hugo; Lizama, Carlos O.; Vega Villa, Oscar; Jerez, Sofia; Briceño, Pedro F.; Thaler, Roman; Riester, Scott M.; Antonelli Anativia, Marcelo; Salazar Onfray, Flavio; Rodríguez Vives, Juan Pablo; Moreno, Ricardo D.; Montecino, Martín; Charbonneau, Martine; Dubois, Claire; Galindo Díaz, Mario; Stein, Gary; van Wijnen, Andre (Wiley-Liss Inc., 2018)
      Osteoblast differentiation is controlled by transcription factor RUNX2 which temporally activates or represses several bone-related genes, including those encoding extracellular matrix proteins or factors that control ...
    • Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A 3 Adenosine ... 
      Torres, Ángelo; Erices, Jose Ignacio; Sanchez, Fabiola; Ehrenfeld, Pamela; Turchi, Laurent; Virolle, Thierry; Uribe, Daniel; Niechi, Ignacio; Spichiger, Carlos; Rocha, José Dellis; Ramirez, Marcos; Salazar Onfray, Flavio; San Martín, Rody; Quezada, Claudia (Elsevier Ireland Ltd, 2019)
      Glioblastoma (GBM) is the brain tumor with the worst prognosis composed of a cell subpopulation called Glioblastoma Stem-like Cells (GSCs) responsible for tumor recurrence mediated by cell invasion. GSCs persist in a hypoxic ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 
      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated ... 
      Durán Aniotz, Claudia; Segal, Gabriela; Salazar, Lorena; Pereda, Cristián; Falcón, Cristián; Tempio, Fabián; Aguilera, Raquel; González González, Rodrigo; Pérez Núñez, Claudio; Tittarelli, Andrés; Catalán Martina, Diego; Nervi, Bruno; Larrondo Lillo, Milton; Salazar Onfray, Flavio; López Nitsche, Mercedes (Springer, 2013)
      Introduction Immunization with autologous dendritic cells (DCs) loaded with a heat shock-conditioned allogeneic melanoma cell lysate caused lysate-specific delayed type hypersensitivity (DTH) reactions in a number ...
    • Interleukin 10 decreases MICA expression on melanoma cell surface 
      Serrano, Antonio E.; Menares Castillo, Evelyn; Garrido Tapia, Macarena; Hager Ribeiro, Carolina; Hernández, Carolina J.; Mendoza Naranjo, Ariadna; Gatica Andrades, Marcela; Valenzuela Díaz, Rodrigo; Zúñiga, Roberto; López, Mercedes N.; Salazar Onfray, Flavio; Aguillón, Juan Carlos (2011)
      Natural-killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC) class I chain-related proteins (MIC) and UL16-binding proteins (ULBP). It is regarded as a ...
    • IRE1α activation in bone marrow-derived dendritic cells modulates innate recognition of melanoma cells and ... 
      Medel, Bernardita; Costoya, Cristobal; Fernandez, Dominique; Pereda, Cristian; Lladser, Alvaro; Sauma, Daniela; Pacheco, Rodrigo; Iwawaki, Takao; Salazar Onfray, Flavio; Osorio, Fabiola (Frontiers Media S.A., 2019)
      The IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safeguards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress, and that has also emerged as a key regulator ...
    • Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for ... 
      López, Mercedes N.; Pereda, Cristian; Ramírez, Marcos; Mendoza Naranjo, Ariadna; Serrano, Antonio; Ferreira, Arturo; Poblete, Rodrigo; Kalergis, Alexis M.; Kiessling, Rolf; Salazar Onfray, Flavio (2007)
      PURPOSE. Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target ...
    • Modulation of established murine collagen-induced arthritis by a single inoculation of short-term ... 
      Salazar, L.; Aravena, O.; Abello, P.; Escobar, A.; Contreras Levicoy, Juan; Rojas Colonelli, Nicole; Catalán Martina, Diego; Aguirre A., Luz María; Zúñiga, R.; Pesce Reyes, Bárbara; González, C.; Cepeda, R.; Cuchacovich Turteltaub, Miguel; Molina, M. C.; Salazar Onfray, Flavio; Delgado, M.; Toes, R. E.; Aguillón Gutiérrez, Juan Carlos (2008)
      Background: The use of regulatory or immature dendritic cells (DCs) as tools for modulating experimental rheumatoid arthritis is very recent. Tumour necrosis factor (TNF)-stimulated DCs have been shown to restore tolerance ...
    • Molecular signatures associated with tumor-specific immune response in melanoma patients treated with ... 
      García-Salum, Tamara; Villablanca, Andrea; Matthäus, Franziska; Tittarelli, Andrés; Baeza, Mauricio; Pereda, Cristián; Gleisner Muñoz, María Alejandra; González, Fermín; López, Mercedes; Hoheisel, Jörg; Norgauer, Johannes; Gebicke Haerter, Peter; Salazar Onfray, Flavio (Impact Journals LLC, 2018)
      Purpose: We previously showed that autologous dendritic cells (DCs) loaded with an allogeneic heat shock (HS)-conditioned melanoma cell-derived lysate, called TRIMEL, induce T-cell-mediated immune responses in stage IV ...
    • Molluskan hemocyanins activate the classical pathway of the human complement system through natural antibodies 
      Pizarro Bauerle, Javier; Maldonado, Ismael; Sosoniuk Roche, Eduardo Rodrigo; Vallejos, Gerardo; López, Mercedes N.; Salazar Onfray, Flavio; Aguilar Guzmán, Lorena Andrea; Valck Calderón, Carolina Eliana; Ferreira, Arturo; Becker, María Inés (Frontiers Research Foundation, 2017)
      © 2017 Pizarro-Bauerle, Maldonado, Sosoniuk-Roche, Vallejos, López, Salazar-Onfray, Aguilar-Guzmán, Valck, Ferreira and Becker. Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable ...