Browsing by Author "Santibáñez, Juan Francisco"
Now showing items 1-11 of 11
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Guerrero, Javier; Santibáñez, Juan Francisco; González, Alfonso; Martínez Winkler, Jorge (Elsevier Inc., 2004)Urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) are ubiquitous receptors involved in the control of a variety of cellular processes frequently found altered in cancer cells. ...
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Guerrero, Javier; Santibáñez, Juan Francisco; González, Alfonso; Martínez, Jorge (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-01-01)Urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) are ubiquitous receptors involved in the control of a variety of cellular processes frequently found altered in cancer cells. ...
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Jerkic, Mirjana; Rivas Elena, Juan V.; Santibáñez, Juan Francisco; Prieto, Marta; Rodríguez Barbero, Alicia; Pérez Barriocanal, Fernando; Pericacho, Miguel; Arévalo, Miguel; Vary, Calvin P.H.; Letarte, Michelle; Bernabeu, Carmelo; López Novoa, José M. (LIPPINCOTT WILLIAMS & WILKINS, 2006-08-04)The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of ...
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Juretic Díaz, Nevenka Militza; Santibáñez, Juan Francisco; Hurtado, Claudia; Martínez, Jorge (Wiley-Liss, 2001)Bone metastases from prostate origin generate an osteoblastic reaction that is expressed in vitro by increased osteoblast proliferation. The urokinase-like plasminogen activator (u-PA) present in the media conditioned ...
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Santibáñez, Juan Francisco; Hurtado, Claudia (ELSEVIER SCIENCE BV, 2005-11-21)Efforts have been made to develop a chemoprevention that selectively triggers apoptosis in malignant cancer cells. Here, we demonstrated that a mutated Ha-Ras activity is required in Anisomycin-induced apoptosis in transformed ...
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Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibáñez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (ELSEVIER, 2006-08-07)We have recently shown that hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFKB is regulated in cultured ...
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Santibáñez, Juan Francisco (ELSEVIER, 2006-10-02)In this study we analyzed the role of the c-Jun N-terminal kinases (JNK) pathway in the TGF-beta 1 stimulation of urokinase-type plasminogen activator (uPA), initial stages of epithelial-mesenchymal transdifferentiation ...
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Martínez Winkler, Jorge; Silva, Sofía; Santibáñez, Juan Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1996-04)Bone metastasis is a common event and a major cause of morbidity in prostate cancer patients. After colonization of bone, prostate cells induce an osteoblastic reaction which is not associated with marrow fibrosis ...
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Tobar, Nicolás; Cáceres, Mónica; Santibáñez, Juan Francisco; Smith, Patricio C.; Martínez, Jorge (Elsevier Inc., 2008-08-18)modulate the migratory properties in MCF-7 and T47D human mammary cell lines. We also described that the NFjB pathway exerts a downstream control on the expression of the ROS-dependent cellular migratory potential. These ...
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Santibáñez, Juan Francisco; Kocic, Jelena; Fabra, Angels; Cano, Amparo; Quintanilla, Miguel (ELSEVIER, 2010)Transforming growth factor-b1 (TGF-b1) activates Rac1 GTPase in mouse transformed keratinocytes. Expression of a constitutively active Q61LRac1 mutant induced an epithelial to mesenchymal transition (EMT) linked to ...
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Santibáñez, Juan Francisco; Quintanilla, Miguel; Martínez, Jorge (Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies., 2002-04-18)We have examined the effect of transforming growth factor L1 (TGF-L1) and overexpression of the Smad4 gene on the phenotype of Car C, a ras mutated highly malignant spindle carcinoma cell line. TGF-L1-treated Car C cells ...