Browsing by Author "Sapag Hagar, Mario"
Now showing items 1-11 of 11
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Muñoz, Aira; Lavandero González, Sergio; Donoso, Eduardo; Puente Piccardo, Javier; Sapag Hagar, Mario (1985)The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct ...
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Lavandero González, Sergio; Cartagena,; Guarda,; Corbalan,; Godoy,; Sapag Hagar, Mario; Jalil, (1993)Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ...
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Lavandero González, Sergio; Cartagena, Gastón; Guarda, Eduardo; Corbalán, Ramón; Godoy, Iván; Sapag Hagar, Mario; Jalil Milad, Jorge (Oxford University Press, 1993)Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ...
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Cartagena,; Sapag Hagar, Mario; Jalil,; Tapia,; Guarda,; Foncea,; Corbalan,; Ebensperger,; Lavandero González, Sergio (1993)Modification of cardiac β-adrenergic receptors (β-AR), resulting from the stimulation of the sympathetic nervous system, is one of the most important factors in the generation of cardiac hypertrophy and heart failure. In ...
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Piddo Mijares, Ana María; Sánchez, María Isabel; Sapag Hagar, Mario; Corbalán, Ramón; Foncea, Rocío; Ebensperger González, Roberto; Godoy, Iván; Meléndez, Jaime; Jalil Milad, Jorge; Lavandero González, Sergio (Academic Press, 1996)The role of cyclic AMP-dependent protein kinase (PKA) and systolic function during the development of left ventricular hypertrophy (LVH) still remain uncertain. The aim of this work is to study PKA activity and mechanical ...
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Lavandero González, Sergio; Ferez, V.; Foncea, R.; Sapag Hagar, Mario; Leroilh, D. (1997)Because IGF- lisa natural cardioprotective which migh; improve cardiac function and stimulates growth and proliferation of carfiac myocytes, there is considerable interest to elucidate the molecular f!iechanisms by which ...
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Foncea, Rocío; Andersson, Monica; Ketterman, Albert; Blakesley, Vicky; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (1997)In response to insulin-like growth factor-I (IGF-I), neonatal rat cardiac myocytes exhibit a hypertrophic response. The elucidation of the IGF- I signal transduction system in these cells remains unknown. We show here that ...
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Arancibia Orrego, Aquiles Antonio; Sapag Hagar, Mario (1993)
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Ebensperger González, Roberto; Acevedo, Erika; Meléndez, Jaime; Corbalán, Ramón; Acevedo, Mónica; Sapag Hagar, Mario; Jalil Milad, Jorge; Lavandero González, Sergio (Academic Press Inc., 1998)There is evidence that insulin-like growth factor-1 (IGF-1) plays a role in the development of left ventricular hypertrophy, but it is uncertain whether cardiac IGP-1 changes before or after hypertension is established, ...
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Tapia Tapia, Alejandra; Costa, Hellen; Moris,; Sapag Hagar, Mario; Valenzuela,; Basualto, Javier (2002)The dissolution profiles of formulations based on mixtures of chitosan/alginate depend on the pH. It is possible to distinguish two processes: (a) a fast kinetic drug release up to 180 min, where the pH value changes from ...
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Lavandero González, Sergio; Donoso, Eduardo P.; Sapag Hagar, Mario (1985)