Browsing by Author "Sauma Mahaluf, Daniela"
Now showing items 1-20 of 21
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(Frontiers Media, 2015)The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction ...
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(Wiley-Blackwell, 2015)CD4+CD25+Foxp3+ regulatory T (Treg) cells mediate immunological self-tolerance and suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has been reported to enhance the differentiation of ...
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(Elsevietr, 2015)Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
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(Universidad de Chile, 2020)La respuesta inmune mediada por los linfocitos T (LT) CD8+ requiere que estas células sean capaces de diferenciarse hacia células efectoras citotóxicas y de memoria que puedan producir una respuesta cada vez más efectiva. ...
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(Wiley & Sons, 2015)The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
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(SOC BIOLGIA CHILE, 2010-08-12)One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
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(ELSEVIER, 2003-11)The mode of action of cyclosporine (CsA) has been ascribed to its capacity to inhibit IL-2 and IFNgamma production by T cells, two cytokines implicated in allograft rejection. Recently, it has been reported that upon ...
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(2013)Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increase in the percentage of autoreactive B and T lymphocytes. Since dendritic cells (DCs) are essential for B cell and T cell function, ...
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(ELSEVIER, 2010)Background. CD4 CD25 Foxp3 regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression ...
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(Universidad de Chile, 2023)Los linfocitos T CD8+ son células del sistema inmune adaptativo que, una vez activadas por células presentadoras de antígenos, se diferencian a células citotóxicas cumpliendo un rol importante en la respuesta inmune ...
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(Universidad de Chile, 2017)En el cáncer, la compleja relación espacio-temporal entre las células tumorales y su microambiente es determinante en el crecimiento, invasión y capacidad de metástasis de los tumores. Es por eso que el estudio de esta ...
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(Universidad de Chile, 2018)Las Gap Junctions (GJs) son clústers de canales intercelulares localizados en la membrana plasmática que permiten la comunicación directa entre células adyacentes. Cada canal GJ está compuesto por 2 hemicanales hexaméricos ...
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(Universidad de Chile, 2018)El desarrollo de una respuesta inmune anti-tumoral requiere de la comunicación entre diferentes células del sistema inmune, así como del reconocimiento de la célula tumoral. Una vez que los Linfocitos T Citotóxicos (CTL) ...
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(Universidad de Chile, 2019)Diversos mecanismos de edición génica se han implementado a lo largo de los años para mutar el genoma del virus herpes simple tipo 2 (VHS-2). Éstos se han basado principalmente en el uso de procesos de recombinación homóloga. ...
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(2004)Dendritic cells (DCs) generated in vitro from bone marrow precursors using granulocyte-macrophage colony-stimulating factor (GM-CSF) secrete interleukin-2 (IL-2) upon activation, an event probably associated to the ...
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(Blackwell Publishing, 2013)T helper type 17 (Th17) lymphocytes are found in high frequency in tumour-burdened animals and cancer patients. These lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, ...
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(2007)Knowledge of lymphocyte migration has become a major issue in our understanding of acquired immunity. The selective migration of naive, effector, memory and regulatory T-cells is a multiple step process regulated by a ...
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(Universidad de Chile, 2019)La función supresora de las células T reguladoras (Tregs) puede tener efectos negativos sobre la respuesta inmune antitumoral. Por lo tanto, es de gran importancia estudiar los factores que alteran la eficiencia de su ...
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(ELSEVIER SCIENCE INC, 2009-07)CD4 CD25 Foxp3 regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune responses. In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor- (TGF- ...
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(Hindawi, 2013)One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival ...
