Browsing by Author "Segura Aguilar, Juan Ernesto"

Now showing items 1-6 of 6

    • Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity 
      Segura Aguilar, Juan Ernesto; Mannervik, Bengt; Inzunza, José; Varshney, Mukesh; Nalvarte, Iván; Muñoz Salvatierra, Patricia Alejandra (Wolters Kluwer, 2022)
      Astrocytes protect neurons by modulating neuronal function and survival. Astrocytes support neurons in several ways. They provide energy through the astrocyte-neuron lactate shuttle, protect neurons from excitotoxicity, ...
    • Dopamine and L-Dopa as selective endogenous neurotoxins 
      Segura Aguilar, Juan Ernesto; Ahumada Castro, Ulises; Paris, Irmgard (2023)
      Selective neurotoxins have the ability to exert their neurotoxic effects in dopaminergic neurons. This could depend on their affinity to the dopamine transporter. The possible molecular mechanisms involved in dopamine and ...
    • Generation of nonviral integration-free human iPS cell line KISCOi001-A from normal human fibroblasts, under ... 
      Inzunza, José; Arias Fuenzalida, Jonathan Lee; Segura Aguilar, Juan Ernesto; Nalvarte, Iván; Varshney, Mukesh (Elsevier, 2021)
      KISCOi001-A is a healthy feeder-free and fully characterized human induced pluripotent stem (iPS) cell line cultured under xeno-free and defined conditions. The cell line is generated from normal human foreskin fibroblasts ...
    • Mechanisms of Dopamine Oxidation and Parkinson’s Disease 
      Segura Aguilar, Juan Ernesto; Paris, Irmgard (Springer, 2023)
      Dopamine’s ability to oxidize to aminochrome explains why this molecule may be a neurotoxic compound that induces toxicity in both cell lines and animal models. Spontaneous dopamine oxidation is prevented by vesicular ...
    • RCSN Cell System for Identifying Dopaminergic Neurotoxicity 
      Caviedes Fernández, Pablo Andrés; Caviedes, Raúl; Segura Aguilar, Juan Ernesto (Springer, 2022)
      Dopaminergic toxicity represents a potential mechanism underlying Parkinson’s disease (PD) neuropathology. Nevertheless, the study of such a mechanism is hampered by the lack of permanent and stable in vitro models that ...
    • State and perspectives on flavonoid neuroprotection against aminochrome-induced neurotoxicity 
      Silva, Víctor; Segura Aguilar, Juan Ernesto (Wolters Kluwer Medknow Publications, India, 2021)