Browsing by Author "Sierra Cristancho, Alfredo José"

Now showing items 1-5 of 5

    • Humanized mouse models for the study of periodontitis: An opportunity to elucidate unresolved aspects of ... 
      Rojas, Carolina; García, Michelle P.; Polanco, Alan F.; González Osuna, Luis; Sierra Cristancho, Alfredo José; Melgar Rodríguez, Samanta Azucena; Cafferata Chea, Emilio Alfredo; Vernal Astudillo, Rolando Marcelo (Frontiers Media, 2021)
      Periodontitis is an oral inflammatory disease in which the polymicrobial synergy and dysbiosis of the subgingival microbiota trigger a deregulated host immune response, that leads to the breakdown of tooth-supporting ...
    • Micro-tomographic characterization of the root and canal system morphology of mandibular first premolars ... 
      Sierra Cristancho, Alfredo José; González Osuna, Luis; Poblete, Daniela; Cafferata Chea, Emilio Alfredo; Carvajal Pavez, Paola Lorena; Lozano Moraga, Carla Paola; Vernal Astudillo, Rolando Marcelo (Nature, 2021)
      This study aimed to analyze the root anatomy and root canal system morphology of mandibular first premolars in a Chilean population. 186 teeth were scanned using micro-computed tomography and reconstructed three-dimensionally. ...
    • Natural Killer T (NKT) cells and periodontitis: potential regulatory role of NKT10 cells 
      Melgar Rodríguez, Samanta Azucena; Cafferata Chea, Emilio Alfredo; Díaz, Nicolás I.; Peña, Miguel A.; González Osuna, Luis; Rojas, Carolina; Sierra Cristancho, Alfredo José; Cárdenas, Angélica M.; Díaz Zúñiga, Jaime; Vernal Astudillo, Rolando Marcelo (Hindawi, 2021)
      Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT ...
    • Premature senescence of T-cells favors bone loss during osteolytic diseases. A new concern in the osteoimmunology ... 
      González Ouna, Luis Gustavo; Sierra Cristancho, Alfredo José; Rojas Pérez, Carolina Isabel; Cafferata Chea, Emilio Alfredo; Melgar Rodríguez, Samanta Azucena; Cárdenas Gutiérrez, Angélica María; Vernal Astudillo, Rolando Marcelo (International Society on Aging and Disease, USA, 2021)
      Cellular senescence is a biological process triggered in response to time-accumulated DNA damage, which prioritizes cell survival over cell function. Particularly, senescent T lymphocytes can be generated prematurely during ...
    • Senescent CD4+CD28− T lymphocytes as a potential driver of Th17/Treg imbalance and alveolar bone resorption ... 
      González Oosuna, Luis Gustavo; Sierra Cristancho, Alfredo José; Cafferata Chea, Emilio Alfredo; Melgar Rodríguez, Samanta Azucena; Rojas Pérez, Carolina Isabel; Carvajal Pavez, Paola Lorena; Cortez, Cristian; Vernal Astudillo, Rolando Marcelo (MDPI, 2022)
      Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation. During chronic inflammatory diseases, infiltrating CD4(+) T ...