Browsing by Author "Simirgiotis, Mario"
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Cornejo, Alberto; Caballero, Julio; Simirgiotis, Mario; Torres, Vanessa; Sánchez, Luisa; Díaz, Nicolás; Guimaraes, Marcela; Hernández, Marcos; Areche Medina, Carlos Alberto; Alfaro, Sergio; Caballero, Leonardo; Melo, Francisco (Taylor & Francis Ltd., 2021)Parkinson’s disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit ...
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Parra, Teresa; Benites, Julio; Ruiz, Lina M.; Sepúlveda, Beatriz; Simirgiotis, Mario; Areche Medina, Carlos (Elsevier, 2015)Seventeen compounds (2-18) synthetized from the diterpenoid ent-beyer-15-en-18-ol (1) isolated from aerial part of Baccharis tola were tested for their gastroprotective activity on the model of HCl/EtOH-induced gastric ...
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Sepúlveda, Beatriz; Quispe, Cristina; Simirgiotis, Mario; García Beltrán, Olimpo; Areche Medina, Carlos (Elsevier, 2016)Mulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the ...
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Areche, Carlos; Fernández Burgos, Ronald; De Terrones, Teresa Cano; Simirgiotis, Mario; García Beltrán, Olimpo; Bórquez, Jorge; Sepúlveda, Beatriz (MDPI AG, 2019)Mulinum crassifolium Phil. (Apiaceae) is an endemic shrub from Chile commonly used as infusion in traditional medicine to treat diabetes, bronchial and intestinal disorders and stomach ailments, including ulcers. From the ...