Browsing by Author "Simon, Felipe"

Now showing items 1-9 of 9

    • Ca-v beta(2) transcription start site variants modulate calcium handling in newborn rat cardiomyocytes 
      Moreno, Cristian; Hermosilla, Tamara; Morales, Danna; Encina, Matías; Torres Díaz, Leandro; Díaz, Pablo; Sarmiento, Daniela; Simon, Felipe; Varela, Diego (Springer, 2015)
      In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit Ca(V)1.2 and the auxiliary subunits Ca-V alpha(2)delta(1) and Ca-V ...
    • Human peritoneal mesothelial cell death induced by high-glucose hypertonic solutioninvolves Ca2+ and Na+ ... 
      Simon, Felipe; Tapia, Pablo; Armisen Yáñez, Ricardo; Echeverría, César; Gatica, Sebastián; Vallejos, Alejandro; Pacheco Durán, Alejandro; Sanhueza Villanueva, María Eugenia; Alvo Abodovsky, Miriam; Segovia, Erico; Torres, Rubén (Frontiers Media, 2017)
      Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD, ...
    • Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic ... 
      González, Andrea; Valero Breton, Mayalen; Huerta Salgado, Camila Francisca; Achiardi, Oscar; Simon, Felipe; Cabello Verrugio, Claudio Alejandro (Pagepress, 2021)
      Sarcopenia is a highly prevalent complication of non-alcoholic fatty liver disease (NAFLD). We aimed to conduct a systematic review and meta-analyses to elucidate the exercise training (ET)'s efficacy on NAFLD adult patients' ...
    • Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent ... 
      Sarmiento, Daniela; Montorfano, Ignacio; Cerda Arancibia, Óscar; Cáceres, Mónica; Becerra, Álvaro; Cabello Verrugio, Claudio; Elorza, Alvaro A.; Riedel, Claudia; Tapia, Pablo; Velásquez, Luis A.; Varela, Diego; Simon, Felipe (Elsevier, 2015)
      A hallmark of severe inflammation is reactive oxygen species (ROS) overproduction induced by increased inflammatory mediators secretion. During systemic inflammation, inflammation mediators circulating in the bloodstream ...
    • Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans 
      Simon, Felipe; Varela Lekanda, Diego; Cabello Verrugio, Claudio (Elsevier, 2013)
      The transient receptor potential melastatin (TRPM) protein family is an extensive group of ion channels expressed in several types of mammalian cells. Many studies have shown that these channels are crucial for performing ...
    • P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells 
      Varela Lekanda, Diego; Penna, Antonello; Simon, Felipe; Eguiguren Ossa, Ana; Leiva Salcedo, Elías; Cerda, Oscar; Sala, Francisco; Stutzin Schottlander, Andrés (2010-03-05)
      Volume-sensitive outwardly rectifying (VSOR) Cl channels are critical for the regulatory volume decrease (RVD) response triggered upon cell swelling. Recent evidence indicates that H2O2 plays an essential role in the ...
    • TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of ... 
      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverría, César; Andaur, Rodrigo; Michea Acevedo, Luis; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (Wiley, 2019)
      Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐ dependent monovalent cation channel, which depolarizes the plasma cell membrane, thereby modulating Ca2+ influx across Ca2+‐permeable ...
    • TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility 
      Cáceres Lluch, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Aníbal; Colombo Flores, Alicia; Leiva Salcedo, Elías; Varela Lekanda, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Óscar; Simon, Felipe; Toledo Araya, Héctor; Park, Kang-Sik; Trimmer, James S.; Cerda, Óscar (Public Library Science, 2015)
      Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a ...
    • TRPM4 regulates Akt/GSK3-b activity and enhances b-catenin signaling and cell proliferation in prostate ... 
      Sagredo, A.; Sagredo, Eduardo A.; Cappelli, Claudio; Baez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (John Wiley, 2018)
      Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...