Browsing by Author "Stojanova, Jana"

Now showing items 1-6 of 6

Artículo

Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through ...

Varela Figueroa, Nelson; Quiñones Sepúlveda, Luis; Stojanova, Jana; Garay, Joselyn; Cáceres Lillo, Dante; Céspedes, Silvia; Sasso, Jaime; Miranda, Carla (Elsevier, 2015)

We tested the influence of four polymorphisms and gene duplication in CYP2D6 on in vivo enzyme activity in a Chilean mestizo population in order to identify the most relevant genetic profiles that account for observed ...
Artículo

Characterization of the CYP2D6 drug metabolizing phenotypes of the Chilean mestizo population through ...

Varela, Nelson; Quiñones Sepúlveda, Luis; Stojanova, Jana; Garay, Joselyn; Cáceres, Dante; Cespedes, Silvia; Sasso, Jaime; Miranda, Carla (Elsevier, 2016)
Artículo

Effect of CYP3A4, CYP3A5, MDR1 and POR genetic polymorphisms in immunosuppressive treatment in chilean ...

Contreras Castillo, Stephania Nichols; Plaza, Anita; Stojanova, Jana; Navarro, Gustavo; Carmona, Rodolfo; Corvalán, Fernando; Cerpa, Leslie; Sandoval, Christopher; Muñoz, Daniel; Leiva, Marina; Castañeda Sepúlveda, Luis Eduardo; Farías, Nayaret; Álvarez, Carolina; Llull Morchio, Gabriel Eduardo; Mezzano, Sergio; Ardiles, Leopoldo; Varela Figueroa, Nelson Miguel; Rodríguez, María S.; Flores, Claudio; Cayún, Juan Pablo; Krall Opazo, Paola Margarita; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)

Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and ...
Artículo

Genetic polymorphisms in the immune response: A focus on kidney transplantation

Stojanova, Jana; Pouche, Lucie; Picard, Nicolas (Elsevier, 2016)

The modulation of the immune system following solid organ transplantation has made considerable progress with new immunosuppressive regimens and has considerably improved rejections rates. The improvement in long-term ...
Artículo

Impact of CYP2C19 genetic polymorphisms on voriconazole dosing and exposure in adult patients with invasive ...

Lamoureux, Fabien; Duflot, Thomas; Woillard, Jean-Baptiste; Metsu, David; Pereira, Tony; Compagnon, Patricia; Morisse-Pradierd, Hélène; El Kholy, Mona; Thiberville, Luc; Stojanova, Jana; Thuillez, Christian (Elsevier, 2016)

Voriconazole (VCZ) use is limited by its narrow therapeutic range and significant interpatient variability in exposure. This study aimed to assess (i) the impact of CYP2C19 genotype on VCZ exposure and (ii) the doses ...
Artículo

New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of ...

Pouche, Lucie; Stojanova, Jana; Marquet, Pierre; Picard, Nicolas (Future Medicine, 2016)

Interindividual variability in immunosuppressive drug responses might be partly explained by genetic variants in proteins involved in the immune response or associated with IS pharmacodynamics. On a general basis, the ...