Browsing by Author "Tobar, Nicolás"
Now showing items 1-8 of 8
-
Villarroel, Pia; Reyes Jedlicki, Marcela; Fuentes, Cecilia; Segovia, María Pia; Tobar, Nicolás; Villalobos, Elisa; Martínez Winkler, Jorge; Hugo, Eric; Ben-Jonathan, Nira; Cifuentes, Mariana (Springer, 2013)We established that human adipose cells and the human adipose cell line LS14 express the calciumsensing receptor (CaSR) and that its activation induces inflammatory cytokine production. Also, its expression is enhanced ...
-
Cáceres, Mónica; Tobar, Nicolás; Guerrero, Javier; Smith, Patricio C.; Martínez, Jorge (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells. These cells ...
-
Cifuentes, Mariana; Fuentes, Cecilia; Tobar, Nicolás; Acevedo, Ingrid; Villalobos, Elisa; Hugo, Eric; Ben-Jonathan, Nira; Reyes Jedlicki, Marcela (Elsevier, 2012)The proinflammatory status of adipose tissue has been linked to the metabolic and cardiovascular consequences of obesity. Human adipose cells express the calcium sensing receptor (CaSR), and its expression is elevated ...
-
Salgado, Daniela (Universidad de Chile, 2022)La obesidad es una patología con alta prevalencia y morbi-mortalidad. El desafío de frenar esta pandemia involucra distintas disciplinas, y la ciencia básica ha planteado como causa fisiopatológica la existencia de ...
-
Tobar, Nicolás; Guerrero, Javier; Smith, Patricio C.; Martínez, Jorge (NATURE PUBLISHING GROUP, 2010-09-28)BACKGROUND: The influence of the stromal microenvironment on the progression of epithelial cancers has been demonstrated. Unravelling the mechanisms by which stromal cells affect epithelial behaviour will contribute in ...
-
Vera Castillo, María Jesús (Universidad de Chile, 2023)Tanto el cáncer de mama como la obesidad representan patologías de alta prevalencia mundial. En la actualidad, se ha relacionado la obesidad como factor de riesgo para el desarrollo de cáncer de mama del tipo receptor de ...
-
Tobar, Nicolás; Cáceres, Mónica; Santibáñez, Juan Francisco; Smith, Patricio C.; Martínez, Jorge (Elsevier Inc., 2008-08-18)modulate the migratory properties in MCF-7 and T47D human mammary cell lines. We also described that the NFjB pathway exerts a downstream control on the expression of the ROS-dependent cellular migratory potential. These ...
-
Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar Oliva, Paula; Dotor, Javier; Smith, Patricio C.; Martínez Winkler, Jorge (Springer Science+Business Media, 2011)In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic response. ...