Browsing by Author "Tuñón, Iñaki"

Now showing items 1-3 of 3

    • Exploration of the activation mechanism of the epigenetic regulator MLL3: A QM/MM study 
      Miranda Rojas, Sebastián; Blanco Esperguez, Kevin; Tuñón, Iñaki; Kästner, Johannes; Mendizábal Emaldia, Fernando Javier (MDPI, 2021)
      The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several ...
    • Studying the phosphoryl transfer mechanism of the: E. coli phosphofructokinase-2: From X-ray structure to ... 
      Murillo López, Juliana; Zinovjev, Kirill; Pereira, Humberto; Caniuguir, Andrés; Garratt, Richard; Babul, Jorge; Recabarren, Rodrigo; Alzate Morales, Jans; Caballero, Julio; Tuñón, Iñaki; Cabrera, Ricardo (Royal Society of Chemistry, 2019)
      Phosphofructokinases (Pfks) catalyze the ATP-dependent phosphorylation of fructose-6-phosphate (F6P) and they are regulated in a wide variety of organisms. Although numerous aspects of the kinetics and regulation have been ...
    • Unraveling the role of the tyrosine tetrad from the binding site of the epigenetic writer MLL3 in the ... 
      Blanco Esperguez, Kevin; Tuñón, Iñaki; Kästner, Johannes; Mendizábal Emaldía, Fernando Javier; Miranda Rojas, Sebastián (MDPI, 2022)
      MLL3, also known as KMT2C, is a lysine mono-methyltransferase in charge of the writing of an epigenetic mark on lysine 4 from histone 3. The catalytic site of MLL3 is composed of four tyrosines, namely, Y44, Y69, Y128, and ...