Browsing by Author "Urbina, Fabiola"
Now showing items 1-9 of 9
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Moreira Ramos, Sandra; Rojas, Diego; Montes, Matías; Urbina, Fabiola; Miralles, Vicente; Maldonado, Edio (Wiley-Blackwell, 2015)In Schizosaccharomycespombe, ribosomal protein gene (RPG) promoters contain a TATA analogue element called the HomolD box. The HomolD-binding protein Rrn7 forms a complex with the RNA polymeraseII machinery. Despite the ...
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Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado Maldonado, Edio (Public Library Science, 2018)Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria ...
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Maldonado Maldonado, Edio; Rojas, Diego A.; Moreira Ramos, Sandra; Urbina, Fabiola; Miralles, Vicente J.; Solari Illescas, Aldo; Venegas Hermosilla, Juan Antonio (Springer, 2015)Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major parasitic disease that affects millions of people in America. However, despite the high impact of this disease on human health, no effective and ...
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Maldonado Maldonado, Edio Luis; Morales Pisón, Sebastián; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo (Frontiers Media, 2021)Trypanosomatids are a group of primitive unicellular eukaryotes that can cause diseases in plants, insects, animals, and humans. Kinetoplast genome integrity is key to trypanosomatid cell survival and viability. Kinetoplast ...
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Contreras Levicoy, Juan; Urbina, Fabiola; Maldonado Maldonado, Edio (BLACKWELL, 2008-06)The positive cofactor 4 (PC4) protein has an important role in transcriptional activation, which has been proposed to be mediated by transcription factor IIA (TFIIA) and TATA-binding protein-associated factors. To test ...
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Maldonado Maldonado, Edio Luis; Rojas, Diego A.; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo (Public Library Science, 2021)The unicellular protozoan Trypanosoma cruzi is the causing agent of Chagas disease which affects several millions of people around the world. The components of the cell signaling pathways in this parasite have not been ...
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Rojas, Diego A.; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo; Maldonado Maldonado, Edio Luis (MDPI, 2022)Positive cofactor 4 (PC4) is a transcriptional coactivator that plays important roles in transcription and DNA replication. In mammals, PC4 is phosphorylated by CK2, and this event downregulates its RNA polymerase II ...
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Maldonado Maldonado, Edio Luis; Rojas, Diego; Urbina, Fabiola; Solari Illescas, Aldo Gerónimo (MDPI, 2021)Chagas disease is a neglected tropical disease caused by the flagellated protozoa Trypanosome cruzi. This illness affects to almost 8-12 million people worldwide, however, is endemic to Latin American countries. It is ...
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Maldonado Maldonado, Edio; Morales Pisón, Sebastian; Urbina, Fabiola; Solari Illescas, Aldo (MDPI, 2022)Chagas disease is caused by the protozoan Trypanosoma cruzi and is endemic to Central and South America. However, it has spread around the world and affects several million people. Treatment with currently available drugs ...