Browsing by Author "Urrutia, Pamela J."

Now showing items 1-7 of 7

    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central ... 
      Urrutia, Pamela J.; Aguirre, Pabla; Esparza, Andrés; Tapia, Victoria; Mena, Natalia P.; Arredondo Olguín, Miguel Armando; González Billault, Christian; Núñez González, Marco (2013)
      Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer’s disease and Parkinson’s disease. The study of the putative association between inflammation and iron ...
    • The interplay between iron accumulation, mitochondrial dysfunction and inflammation during the execution ... 
      Urrutia, Pamela J.; Mena, Natalia P.; Núñez González, Marco (Frontiers Research Foundation, 2014)
      A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's ...
    • Iron toxicity in neurodegeneration 
      Núñez González, Marco; Urrutia, Pamela J.; Mena, Natalia; Aguirre, Pabla; Tapia, Victoria; Salazar, Julio (2012)
      Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, ...
    • Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders 
      Mena, Natalia P.; Urrutia, Pamela J.; Lourido, Fernanda; Carrasco, Carlos M.; Núñez González, Marco (Elsevier, 2015)
      Synthesis of the iron-containing prosthetic groups—heme and iron–sulfur clusters—occurs in mitochondria. The mitochondrion is also an important producer of reactive oxygen species (ROS), which are derived fromelectrons leaking ...
    • New players in neuronal Iron homeostasis: insights from CRISPRi studies 
      Bórquez, Daniel A.; Castro, Francisco; Núñez González, Marco Tulio; Urrutia, Pamela J. (MDPI, 2022)
      Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, ...
    • The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against ... 
      Mena, Natalia P.; García Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro Castillo, Vicente; Cassels Niven, Bruce; Núñez González, Marco (Elsevier, 2015)
      Abundant evidence indicates that iron accumulation, oxidative damage and mitochondrial dysfunction are common features of Huntington's disease, Parkinson's disease, Friedreich's ataxia and a group of disorders known as ...
    • The dopamine metabolite aminochrome inhibits mitochondrial complex i and modifies the expression of iron ... 
      Aguirre, Pabla; Urrutia, Pamela J.; Tapia, Victoria; Villa, Monica; Paris Pizarro, Irmgard; Segura Aguilar, Juan; Núñez González, Marco (2012)
      Hallmarks of idiopathic and some forms of familial Parkinson's disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. There seems to be a causal link ...