Browsing by Author "Varela, Nelson M."

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Artículo

Preliminary pharmacogenomic-based predictive models of tamoxifen response in hormone-dependent chilean ...

Miranda, Carla; Galleguillos, Macarena; Torres, Roberto; Tardon, Karla; Cáceres Lillo, Dante; Lee, Kuen-shiou; Redal, María A.; Varela, Nelson M.; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)

Tamoxifen (TAM), a selective oestrogen receptor modulator, is one of the most used treatments in oestrogen receptor-positive (ER+) early and metastatic breast cancer (BC) patients. The response to TAM has a high degree of ...
Artículo

Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, noalcoholic steatohepatitis ...

Varela, Nelson M.; Quiñones, Luis A.; Orellana, Myriam; Poniachik Teller, Jaime; Csendes Juhasz, Attila; Smok Sahid, Gladys; Rodrigo Salinas, Ramón; Cáceres, Dante D.; Videla Cabrera, Luis (2008)

CYP2E1 enzyme is related to nonalcoholic steatohepatitis (NASH) due to its ability for reactive oxygen species production, which can be influenced by polymorphisms in the gene. The aim of this study was to investigate ...