Browsing by Author "Varela Figueroa, Nelson Miguel"

Now showing items 1-5 of 5

    • Análisis farmacogenético retrospectivo de una paciente pediátrica en tratamiento anticoagulante: caso clínico 
      Cavieres, Mirta; Suárez, Marcelo; Verón, Gabriel; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel (Inst Nacional Salud, Colombia, 2021)
      We present the clinical case of a 10-year-old patient diagnosed with dilated cardiomyopathy who registered INR values above 10 upon receiving standard doses of acenocoumarol, as well as other values reported as uncoagulable, ...
    • Effect of CYP3A4, CYP3A5, MDR1 and POR genetic polymorphisms in immunosuppressive treatment in chilean ... 
      Contreras Castillo, Stephania Nichols; Plaza, Anita; Stojanova, Jana; Navarro, Gustavo; Carmona, Rodolfo; Corvalán, Fernando; Cerpa, Leslie; Sandoval, Christopher; Muñoz, Daniel; Leiva, Marina; Castañeda Sepúlveda, Luis Eduardo; Farías, Nayaret; Álvarez, Carolina; Llull Morchio, Gabriel Eduardo; Mezzano, Sergio; Ardiles, Leopoldo; Varela Figueroa, Nelson Miguel; Rodríguez, María S.; Flores, Claudio; Cayún, Juan Pablo; Krall Opazo, Paola Margarita; Quiñones Sepúlveda, Luis Abel (Frontiers Media, 2021)
      Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and ...
    • Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population 
      Alvarado, Ángel Tito; Muñoz, Ana María; Saravia Bartra, María; Valderrama Wong, Milton; González Aristegui, Daniela; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel; Bendezú, María Rocío; García, Jorge Antonio; Loja Herrera, Berta (Pensoft, 2021)
      The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) ...
    • Frequency of CYP2D6*3 and *4 and metabolizer phenotypes in three mestizo Peruvian populations 
      Alvarado, Ángel T.; Ybáñez Julca, Roberto; Muñoz, Ana María; Tejada Bechi, César; Cerro, Roberto; Quiñones Sepúlveda, Luis Abel; Varela Figueroa, Nelson Miguel; Alvarado, César André; Alvarado, Erick; Bendezú, María R.; García, Jorge A. (Pensoft Publishers, Bulgaria, 2021)
      Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 and 0.051 for CYP2D6*4. The percentages of ...
    • Pharmacogenomics: basis and milestones 
      Cerpa, Leslie C.; Varela Figueroa, Nelson Miguel; Martínez Olguín, Matías; Quiñones Sepúlveda, Luis (Springer, 2021)
      The genomic interindividual heterogeneity for proper pharmacotherapy remains a significant challenge for research, clinical decision-making, and the design of clinical trials. Translation of the obtained genomic information ...