Browsing by Author "Vargas, Leonardo"

Now showing items 1-6 of 6

    • CD73 ectonucleotidase restrains CD8+T cell metabolic fitness and anti-tumoral activity 
      Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Farías, Paula; Vargas, Leonardo; Simon Zegers, María Valeska; Cárdenas, César; Lladser, Álvaro; Salazar Onfray, Flavio Andrés; Elorza, Álvaro A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
    • CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells 
      Flores Santibáñez, Felipe; Fernández, Dominique; Meza, Daniel; Tejón, Gabriela; Vargas, Leonardo; Varela Nallar, Lorena; Arredondo, Sebastián; Guixé Leguía, Victoria Cristina; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Wiley & Sons, 2015)
      The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
    • Dysregulated immune responses in COVID-19 patients correlating with disease severity and invasive oxygen ... 
      García González, Paulina; Tempio Sepúlveda, Fabián Ignacio; Fuentes, Camila; Merino, Consuelo; Vargas, Leonardo; Simon, Valeska; Ramírez Pereira, Mirliana; Rojas, Verónica; Tobar Almonacid, Eduardo Andres; Landskron Ramos, Glauben Tamara; Araya, Juan Pablo; Navarrete, Mariela; Bastías Oñate, Carla Belén; Tordecilla Fernández, Rocío Pilar; Varas, Macarena A.; Maturana, Pablo; Marcoleta Caldera, Andrés Esteban; Allende Connelly, Miguel Luis; Naves Pichuante, Rodrigo Antonio; Hermoso, Marcela Alejandra; Salazar Onfray, Flavio Andrés; López Nitsche, Mercedes Natalia; Bono Merino, María Rosa; Osorio Olivares, Fabiola Beatriz (Frontiers Media, 2021)
      The prognosis of severe COVID-19 patients has motivated research communities to uncover mechanisms of SARS-CoV-2 pathogenesis also on a regional level. In this work, we aimed to understand the immunological dynamics of ...
    • Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens 
      Vargas, Pablo; Cortés, Claudio; Vargas, Leonardo; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (ELSEVIER GMBH, 2005-09-02)
      Dendritic cells (DCs) are the only professional antigen-presenting cells endowed with the ability to stimulate naı¨ve T cells and initiate a primary immune response. For this reason, DC-based immunization has been shown ...
    • Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells 
      Elgueta, Raúl; Sepúlveda, Fernando E.; Vilches, Felipe; Vargas, Leonardo; Mora, J. Rodrigo; Bono Merino, María Rosa; Rosemblatt Silber, Mario César (AMER ASSOC IMMUNOLOGISTS, 2008-05-15)
      It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the ...
    • Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of ... 
      Vargas, Leonardo; Valdivieso Berríos, Nicolás Alejandro; Tempio, Fabián; Simon Zegers, María Valeska; Sauma Mahaluf, Daniela Macarena; Valenzuela Pérez, Lucía Teresita; Beltrán Muñoz, Caroll Jenny; Castillo Delgado, Loriana Cecilia; Contreras Benavides, Ximena Stella; Acevedo Acevedo, Mónica Loreto; Acevedo, Johanna; González, Rafael I.; Valiente Echeverría, Fernando Andres; Soto Rifo, Ricardo Andrés; Rosemblatt Silber, Mario César; López Nitsche, Mercedes Natalia; Osorio Olivares, Fabiola Beatriz; Bono Merino, María Rosa (BMC, 2022)
      Background Chile was severely affected by COVID19 outbreaks but was also one of the first countries to start a nationwide program to vaccinate against the disease. Furthermore, Chile became one of the fastest countries to ...