Browsing by Author "Villa, Mónica"

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Artículo

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy ...

Huenchuguala, Sandro; Muñoz, Patricia; Zavala, Patricio; Villa, Mónica; Urriola Cuevas, Carlos; Ahumada, Ulises; Graumann, Rebecca; Nore, Beston F.; Couve, Eduardo; Mannervik, Bengt; Paris Pizarro, Irmgard; Segura Aguilar, Juan (Taylor and Francis Inc., 2014)

U373MG cells constitutively express glutathione S-transferase mu 2 (GSTM2) and exhibit 3H-dopamine uptake, which is inhibited by 2 μM of nomifensine and 15 μM of estradiol. We generated a stable cell line (U373MGsiGST6) ...
Artículo

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

Urriola Cuevas, Carlos; Huenchuguala, Sandro; Muñoz, Patricia; Villa, Mónica; Paris Pizarro, Irmgard; Mannervik, Bengt; Segura Aguilar, Juan (Springer, 2015)

U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 A mu M aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) ...